| Description | This is a fully human IgG4 antibody that functions as an inhibitor of ANGPTL3, facilitating substantial remodeling of very low-density lipoprotein and resulting in decreased LDL-C levels. The antibody effectively obstructs ANGPTL3, enabling accelerated breakdown of lipids associated with elevated cholesterol. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Human |
| Isotype | Human IgG4, kappa |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein A affinity purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | Inhib |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | ANGPTL3 |
| Alternative Name | Angiopoietin Like 3; Angiopoietin 5; ANGPT5; ANG-5; Angiopoietin-Related Protein 3; Angiopoietin-Like Protein 3 |
| Gene ID | 27329 |
| UniProt | Q9Y5C1 |
| Related pathway | Plasma lipoprotein assembly, remodeling, and clearance and NR1H2 and NR1H3-mediated signaling |
| Research Area | Signal Pathway |
| Related Disease | Atherosclerotic diseases and associated disorders. |
