| Description | This product is a human antibody that binds to the human polyomavirus 1 capsid protein VP1. The mab or engineered derivatives inhibit this recently discovered cancer-causing polyomavirus. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Human polyomavirus 1 (BK virus) |
| Cross Reactivity | BKV VLP ST1; BKV VLP ST2; BKV VLP ST3; BKV VLP ST4 |
| Epitope | E61, R64, and R83 |
| Neutralization Mechanism | The ability of BKV to become resistant to antibody-mediated neutralization in vitro was studied by serial passaging of the virus in RPTE cells in the presence of antibody 41F17. |
| Affinity | KD = 15 ± 3 pM (BKV VLP ST1) KD = 54 ± 13 pM (BKV VLP ST2) KD = 44 ± 20 pM (BKV VLP ST3) KD = 19 ± 5 pM (BKV VLP ST4) |
| Isotype | Human IgG |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein A purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | ELISA; Neut; SPR |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | BK virus VP1 |
| Alternative Name | human polyomaviruses; HPyVs; HPyV; Capsid protein VP1; Capsid protein; VP1; BKV |
| Research Area | Microbiology |
