| Description | This is a recombinant monoclonal antibody of the human IgG1, λ type. The antibody has demonstrated the ability to bind to human and monkey CCR4, while not binding to murine CCR4. Furthermore, it has been proven to effectively inhibit the chemotaxis of CCR4⁺ cells towards a ligand of CCR4. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Human, Monkey |
| IC50 | 43.3 pM |
| Affinity | KD = 0.06 nM |
| Isotype | Human IgG1, lambda |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein A affinity purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | ADCC; Inhib; FC |
| Application Notes | FC: 5 μg/mL |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | CCR4 |
| Alternative Name | C-C Motif Chemokine Receptor 4; Chemokine (C-C Motif) Receptor 4; C-C CKR-4; CC-CKR-4; CMKBR4; CCR-4; K5-5; C-C Chemokine Receptor Type 4 |
| Gene ID | 1233 |
| UniProt | P51679 |
| Related pathway | Class A/1 (Rhodopsin-like receptors) and GPCR downstream signalling |
| Research Area | Immunology; Cardiovascular |
| Related Disease | Infectious diseases and cancer |
