| Sub Cat | Host Species | Affinity | |
|---|---|---|---|
| V3S-1124-YC1641 | Rabbit | 2.7 nM | |
| V3S-0622-YC63 | Human | 8.5 nM |
| Description | This product is a CCR5-specific antibody. The antibody was shown to efficiently prevent the surface expression of CCR5. |
| Clonality | Monoclonal |
| Host Species | Rabbit |
| Target Species | Human |
| Immunogen | Purified CCR5-N-GST protein |
| Epitope | The epitope is located in the amino acids region 14-19 (YYTSEP). |
| Affinity | 2.7 nM |
| Isotype | IgG |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein A affinity purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | ELISA; Block |
| Application Notes | Surface Plasmon Resonance Surface plasmon resonance of rabbit Fab and humanized Fab to CCR5-N-MBP antigen was performed on a Biacore instrument. Binding of Fab to immobilized CCR5-N-MBP was studied by injection of Fab at five different concentrations ranging from 50 to 150 nM. Activation, deactivation, regeneration of the CM5 sensor chip and evaluation of obtained data were done. |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | CCR5 |
| Alternative Name | CKR5; CCR-5; CD195; CKR-5; CCCKR5; CMKBR5; IDDM22; CC-CKR-5; C-C chemokine receptor type 5; C-C motif chemokine receptor 5 A159A; HIV-1 fusion coreceptor; chemokine (C-C motif) receptor 5; chemokine receptor CCR5; chemokine recptor CCR5 Delta32; chemr13 |
| Gene ID | 1234 |
| UniProt | P51681 |
| Research Area | Neuroscience; Immunology |
