CD44 (aa 12-101) Specific Neutra™ Antibody (V3S-0324-FY39), Mouse IgG1 (CAT#: V3S-0324-FY39)

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Datasheet

MSDS

COA

Summary
Property
Applications
Protocols
Target

Summary

Description CD44 (aa 12-101) Antibody (V3S-0324-FY39)y is a mouse IgG1 antibody specific to human CD44. It was designed to target the epitope located within the amino acid sequence 12-101 of the CD44 antigen. The antibody can be used in the inhibition of tumor growth and prevention of post-chemotherapy relapse in human breast cancer. CD44 (aa 21-649) Antibody (V3S-0324-FY40) is a humanized monoclonal antibody that is designed to target the human and Cynomolgus Monkey CD44 protein specifically. The antibody has a high affinity value of 3.17 nM for human CD44 protein. This antibody demonstrates utility in various applications such as Inhib, ELISA, and IHC assays. The anti-CD44 antibody could be used to immunoprecipitate and isolate other forms of the CD44 antigen. The antibody was well-tolerated and significantly inhibited the tumor growth in a human breast cancer xenograft model. The antibody significantly inhibited tumor growth in the PC-3 in vivo established model of human prostate cancer.
Clonality Monoclonal
Host Species Mouse
Target Species Human
Epitope Amino acids 12-101
Isotype Mouse IgG1

Property

Expression Species HEK293F or CHO
Conjugation None
Purity >95%, determined by SDS-PAGE and SEC-HPLC
Endotoxin <1 EU/mg
Purification Protein G affinity purified
Sterility 0.2 μM filtered
Formulation PBS, pH 7.4
Preservation No preservatives
Stabilizer No stabilizers
Storage Store at 4°C within a week. For longer storage, aliquot and store at -20°C.

Applications

Application IHC; Inhib; FC

Protocols

ELISA Enzyme-Linked Immunosorbent Assay Protocol
WB Western Blot Protocol
FC Flow Cytometry Protocol

Target

Target CD44
Alternative Name CD44 Molecule (Indian Blood Group); Hematopoietic Cell E- And L-Selectin Ligand; GP90 Lymphocyte Homing/Adhesion Receptor; Chondroitin Sulfate Proteoglycan 8; Extracellular Matrix Receptor III; Heparan Sulfate Proteoglycan; Phagocytic Glycoprotein 1; Hyaluronate Receptor; Hermes Antigen; CD44 Antigen; ECMR-III; HUTCH-I; Epican; CDW44; MDU2; MDU3
Gene ID 960
UniProt P16070
Related pathway NFκB signaling
Research Area Cancer Research
Related Disease Human breast cancer
For research use only, not directly for clinical use.
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