Description | This humanized monoclonal antibody is designed to target the human and Cynomolgus Monkey CD44 protein specifically. The antibody has a high affinity value of 3.17 nM for human CD44 protein. This antibody demonstrates utility in various applications such as Inhib, ELISA, and IHC assays. The anti-CD44 antibody could be used to immunoprecipitate and isolate other forms of the CD44 antigen. The antibody was well-tolerated and significantly inhibited the tumor growth in a human breast cancer xenograft model. The antibody significantly inhibited tumor growth in the PC-3 in vivo established model of human prostate cancer. |
Clonality | Monoclonal |
Host Species | Human |
Target Species | Human, Cynomolgus |
Affinity | KD = 3.17 nM |
Isotype | Human IgG |
Expression Species | HEK293F or CHO |
Conjugation | None |
Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
Endotoxin | <1 EU/mg |
Purification | Protein A affinity purified |
Sterility | 0.2 μM filtered |
Formulation | PBS, pH 7.4 |
Preservation | No preservatives |
Stabilizer | No stabilizers |
Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
Application | Inhib; ELISA; IHC |
ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
WB | Western Blot Protocol |
FC | Flow Cytometry Protocol |
Target | CD44 |
Alternative Name | CD44 Molecule (Indian Blood Group); Hematopoietic Cell E- And L-Selectin Ligand; GP90 Lymphocyte Homing/Adhesion Receptor; Chondroitin Sulfate Proteoglycan 8; Extracellular Matrix Receptor III; Heparan Sulfate Proteoglycan; Phagocytic Glycoprotein 1; Hyaluronate Receptor; Hermes Antigen; CD44 Antigen; ECMR-III; HUTCH-I; Epican; CDW44; MDU2; MDU3 |
Gene ID | 960 |
UniProt | P16070 |
Related pathway | NFκB signaling |
Research Area | Cancer Research |
Related Disease | Human breast adenocarcinoma |