| Description | This humanized monoclonal antibody is designed to target the human and cynomolgus monkey CD44 protein specifically. The antibody has a high affinity value of 3.17 nM for human CD44 protein. This antibody demonstrates utility in various applications such as Inhib, ELISA, and IHC assays. The anti-CD44 antibody could be used to immunoprecipitate and isolate other forms of the CD44 antigen. The antibody was well-tolerated and significantly inhibited the tumor growth in a human breast cancer xenograft model. The antibody significantly inhibited tumor growth in the PC-3 in vivo established model of human prostate cancer. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Human, Cynomolgus |
| Affinity | KD = 3.17 nM |
| Isotype | Human IgG |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein A affinity purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | Inhib; ELISA; IHC |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | CD44 |
| Alternative Name | CD44 Molecule (Indian Blood Group); Hematopoietic Cell E- And L-Selectin Ligand; GP90 Lymphocyte Homing/Adhesion Receptor; Chondroitin Sulfate Proteoglycan 8; Extracellular Matrix Receptor III; Heparan Sulfate Proteoglycan; Phagocytic Glycoprotein 1; Hyaluronate Receptor; Hermes Antigen; CD44 Antigen; ECMR-III; HUTCH-I; Epican; CDW44; MDU2; MDU3 |
| Gene ID | 960 |
| UniProt | P16070 |
| Related pathway | NFκB signaling |
| Research Area | Cancer Research |
| Related Disease | Human breast adenocarcinoma |
