| Description | This is a humanized monoclonal antibody that targets the human CD79b protein specifically. It exhibits a high binding affinity to human CD79b at 0.44 nM. The huMA79bv28 HC A118C conjugate with PBD, known as "huMA79bv28-PBD," demonstrated significant suppression of tumor growth in SCID mice when compared to both the vehicle and the control ADC. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Human |
| Affinity | KD = 0.44 nM |
| Isotype | Human IgG1 |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein A affinity purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | Inhib |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | CD79b |
| Alternative Name | CD79b Molecule; CD79B Antigen (Immunoglobulin-Associated Beta); CD79b Molecule, Immunoglobulin-Associated Beta; Immunoglobulin-Associated B29 Protein; B-Cell-Specific Glycoprotein B29; Ig-Beta |
| Gene ID | 974 |
| UniProt | P40259 |
| Related pathway | Infectious disease and Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| Research Area | Infectious disease |
| Related Disease | Agammaglobulinemia 6, Autosomal Recessive and Autosomal Agammaglobulinemia |
