| Description | This product is a human antibody with a high affinity for HIV-1 Env. It effectively neutralized 84% of viruses, demonstrating an IC₅₀ of 6.11 μg/ml. Additionally, it exhibited binding activity towards the full-length MPER. Notably, it demonstrated resistance to neutralization mutations and underwent an MPER Ala scan. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Human immunodeficiency virus type 1 (HIV1) |
| Epitope | AA 671-683 |
| IC50 | 6.11 μg/mL |
| Affinity | KD = 9.9 nM |
| Isotype | Human IgG1 |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein A purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | ELISA; Neut |
| Application Notes | PGZL1 was tested against a panel of six viruses and demonstrated the ability to neutralize five of them, with an IC₅₀ of 5.8 μg/ml. |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | HIV-1 Env |
| Alternative Name | HIV-1 envelope protein; HIV-1; envelope protein; Env |
| Research Area | Microbiology |
