| Description |
This antibody is a humanized version of 1D10 was produced using CDR grafting from murine 1D10. The resulting antibody has an affinity that is similar to that of the parental murine antibody. hu1D10 recognizes some, but not all, of the human HLA-DR β chains. Both normal and malignant B cells can express the 1D10 antigen. In addition, the humanized antibody is capable of inducing complement-mediated cytotoxicity, antibody-dependent cell cytotoxicity, and direct apoptosis of 1D10-expressing B cells.
This product is a recombinant human antibody provided by CreativeBiolabs. It was expressed in mammalian cells (293F or CHO) with antibody encoding genes and purified by affinity chromatography. Each lot of this antibody is quality control tested by SDS-PAGE and SEC-HPLC analysis. For highly sensitive assays, we recommend the ultrapurified form of the product, which has a lower endotoxin limit than standard antibody, less than 1 EU/mg or even 0.1 EU/mg. |
