| Description | This product is a human neutralizing antibody specific for Merozoite Surface Protein 1 (MSP-1), which is the abundant and essential for Plasmodium development. This antibody bound to MSP-1 with moderate affinity. It showed potent activity in inhibiting and neutralizing parasite growth of diverse strains. This product has been tested using Enzyme-linked immunosorbent assay, Bio-layer interferometry, Neutralization assay and Inhibition assay. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Plasmodium |
| Epitope | Residues at the central β-sheets and C-terminal loop of EGF-like domain II |
| Affinity | 4.24 nM |
| Isotype | IgG1 |
| Expression Species | HEK293F or CHO cell line |
| Conjugation | Unconjugated |
| Purity | >95% |
| Endotoxin | <1 EU/mg |
| Form | Liquid |
| Purification | Protein A purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics. |
| Application | ELISA; Neut; BLI; Inhib |
| Application Notes | ELISA: 1/4000 Bio-layer interferometry (BLI): The mAb bound to p19 with the strong affinity. The KD to p19 is 4.24 nM. Neutralization assay: the antibody inhibited parasite growth by>90% (against Plasmodium falciparum 3D7) at 1.0 mg/mL. |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | MSP1 |
| Alternative Name | Merozoite Surface Protein 1 |
| Research Area | Infectious Disease |
| Related Disease | Malaria |
