RSV F Specific Neutra™ Antibody (V3S-1023-FY125), Mouse IgG2a, κ (CAT#: V3S-1023-FY125)

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Datasheet

MSDS

COA

Summary
Property
Applications
Protocols
Target

Summary

Description This product is a mouse antibody to RSV F. The antibody recognizes both pre-fusion and post-fusion RSV F and binds strongly to a previously unidentified neutralizing epitope positioned between antigenic sites II and IV in the F1 fragment. The antibody has a high affinity for RSV F NP, with a KD value of 0.07 nM. Additionally, it binds to the site II peptide (residues 254-278) with a KD value of 12.5 nM.
Clonality Monoclonal
Host Species Mouse
Target Species Respiratory Syncytial Virus (RSV)
Immunogen RSV F NP protein
Epitope NSELLSLINDMPITNDQKKLMSNNV (AA 254-278)
IC50 1078 ng/mL
Affinity KD = 0.07 nM (RSV F NP vaccine)
KD = 0.34 nM (post-fusion RSV F)
KD = 7.09 nM (pre-fusion RSV F)
Isotype Mouse IgG2a, κ

Property

Expression Species HEK293F or CHO
Conjugation None
Purity >95%, determined by SDS-PAGE and SEC-HPLC
Endotoxin <1 EU/mg
Purification Protein G purified
Sterility 0.2 μM filtered
Formulation PBS, pH 7.4
Preservation No preservatives
Stabilizer No stabilizers
Storage Store at 4°C within a week. For longer storage, aliquot and store at -20°C.

Applications

Application ELISA; Neut
Application Notes Characterization of RSV F-specific monoclonal antibody binding to RSV with an IC₅₀ of 1.078 μg/mL.

Protocols

ELISA Enzyme-Linked Immunosorbent Assay Protocol
WB Western Blot Protocol
FC Flow Cytometry Protocol

Target

Target RSV F
Alternative Name Human respiratory syncytial virus fusion protein; Human respiratory syncytial virus; fusion protein; F protein; RSV fusion (F) glycoprotein; fusion glycoprotein
Research Area Microbiology
For research use only, not directly for clinical use.
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