| Description | This product is a neutralizing antibody specific for RSV fusion glycoprotein F0. It recognizes both pre-fusion and post-fusion RSV F. It binds with nanomole affinity to a neutralizing epitope located at an intermediate position between antigenic sites II and IV in the F1 fragment. This antibody has potent neutralization ability against RSV. |
| Clonality | Monoclonal |
| Host Species | Mouse |
| Target Species | RSV |
| Immunogen | RSV F NP |
| Epitope | AA 254-278 |
| Neutralization Mechanism | It recognizes both pre-fusion and post-fusion RSV F. |
| IC50 | 1.078 μg/mL |
| Affinity | KD = 12.5 nM |
| Isotype | IgG2a, kappa |
| Expression Species | HEK293F or CHO cell |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Form | Liquid |
| Purification | Protein G purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics. |
| Application | ELISA; SPR; BLI; Neut |
| Application Notes | Surface plasmon resonance (SPR): The affinity of this antibody for the site II peptide (residues 254-278) of RSV F protein was determined to be 12.5 nM. |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | RSV F0 |
| Alternative Name | Human respiratory syncytial virus Fusion glycoprotein F0 |
| Research Area | Infectious Disease |
| Related Disease | Acute lower respiratory tract illness |
