| Sub Cat | Epitope | Isotype | Application | Affinity | |
|---|---|---|---|---|---|
| V3S-1124-YC311 | N-terminal domain (NTD) | ELISA; BLI; Neut | 9.4 nM | ||
| V3S-0623-XY111 | A conformational epitope formed by NTD loops N3 and N5 | IgG1 | ELISA, Neut | ||
| V3S-0623-XY121 | N-terminal domain (NTD) | IgG1 | ELISA, Neut | ||
| V3S-0623-XY95 | N-terminal domain (NTD) | IgG1 | ELISA, Neut | 0.19 nM | |
| V3S-0623-XY77 | The NTD loops region N1 (14-26), N3 (141-156) and N5 (246-260) | IgG1 | ELISA, Neut | ||
| V3S-0623-XY135 | N-terminal domain (NTD) | IgG1 | ELISA | ||
| V3S-0822-YC2775 | The SARS-CoV-2 S1 NTD. | IgG1 kappa | ELISA; SPR |
| Description | The mAb is a N-terminal domain (NTD)-directed antibody. It is a potently neutralizing antibody against the NTD and was protective against lethal viral challenge. This product has been determined by Bio-layer interferometry and Neutralization assay. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | SARS-CoV-2 |
| Epitope | N-terminal domain (NTD) of SARS-CoV-2 spike protein |
| Affinity | 9.4 nM |
| Expression Species | HEK293F or CHO cell line |
| Conjugation | Unconjugated |
| Purity | >95% |
| Endotoxin | <1 EU/mg |
| Form | Liquid |
| Purification | Protein A purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics. |
| Application | ELISA; BLI; Neut |
| Application Notes | The affinity of the antibody for S-ECD was determined by Bio-layer interferometry (BLI) and the KD value is 9.4 nM. The IC₅₀ value is about 0.81 ng/mL against SARS-CoV-2 virus measured by in vitro Neutralization assay. |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | SARS-CoV-2 S |
| Alternative Name | Severe acute respiratory syndrome coronavirus 2 spike ectodomain |
| Research Area | Coronavirus Disease 2019 |
| Related Disease | Coronavirus Disease 2019 |
