| Description | The antibody CV07-270 is a human mAb specific for SARS-CoV-2 Spike S1 protein. The binding of mAbs to unfixed murine tissues was tested. The result revealed it is reactive to smooth muscle from sections of lung, heart, kidney, and colon but not liver. It uses CDR H1, H3, L1, and L2 for RBD interaction. It (IC50 = 82.3 ng/mL) had only 2 SHMs (2/0), did not reduce ACE2 binding in our assay, and showed binding to smooth muscle tissue. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | SARS-CoV-2 |
| Epitope | Receptor-binding domain (RBD) |
| Isotype | IgG1 |
| Expression Species | HEK293F or CHO cell line |
| Conjugation | Unconjugated |
| Purity | >95% |
| Endotoxin | <1 EU/mg |
| Form | Liquid |
| Purification | Protein A purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics. |
| Application | ELISA, Neut |
| Application Notes | The IC₅₀ value of the mAb is 82.3 ng/mL. |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Western Blot Protocol |
| Target | SARS-CoV-2 |
| Alternative Name | Severe acute respiratory syndrome coronavirus 2 |
| Research Area | Coronavirus Disease 2019 |
| Related Disease | Coronavirus Disease 2019 |
