| Description | The anti-SARS-CoV-2 antibody is a mouse IgG, clone Fab22. This product is a recombinant antibody provided by Creative Biolabs. It binds with high affinity to both MERS-CoV and SARS-CoV-2 S proteins, and a combination of electron microscopy and crystal structures localizes the epitope to a conserved coiled-coil region in the S2 subunit. It exhibits potent neutralizing activity, with IC50 values of 0.12 μg/ml. It protects mice against lethal MERS-CoV and SARS-CoV-2 challenge. |
| Clonality | Monoclonal |
| Host Species | Mouse |
| Target Species | SARS-CoV-2 |
| Cross Reactivity | MERS-CoV |
| Epitope | Coiled-coil region in the S2 subunit |
| Isotype | IgG |
| Expression Species | HEK293F or CHO cell line |
| Conjugation | Unconjugated |
| Purity | >95% |
| Endotoxin | <1 EU/mg |
| Form | Liquid |
| Purification | Protein G purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics. |
| Application | ELISA, Neut |
| Application Notes | The mAb exhibits potent neutralizing activity, with IC₅₀ values of 0.12 μg/ml. |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Western Blot Protocol |
| Target | SARS-CoV-2 |
| Alternative Name | Severe acute respiratory syndrome coronavirus 2 |
| Research Area | Coronavirus Disease 2019 |
| Related Disease | Coronavirus Disease 2019 |
