| Description |
This chicken anti-VCTN1 antibody (clone S2) recognizes human VCTN1. S2 interacts with the VCTN1 epitope on these residues: Leu72, Val76, Leu77, Glu82, Glu89, Ser91, Glu92, Trp107, Lys129, Tyr131, Asn140, Asn142. |
| Clonality |
Monoclonal |
| Host Species |
Chicken |
| Target Species |
Human |
| Immunogen |
Recombinant VCTN1 protein (aa 29-258) |
| Epitope |
Leu72, Val76, Leu77, Glu82, Glu89, Ser91, Glu92, Trp107, Lys129, Tyr131, Asn140, Asn142 |
| Neutralization Mechanism |
This antibody S2 can effectively neutralize the immunosuppression response induced by B7-H4 proteins and enabling T-cells to retain their activation status. |
| Function |
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation. |
| Isotype |
Chicken IgY |
