| Description | This product is an antibody that blocks human FcRn. It also blocks FcRn in nonhuman primates (NHPs), such as cynomolgus monkey. The antibody decreased all IgG subtypes and IgG ICs in the circulation of human. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Human, Cynomolgus |
| Affinity | KD = 1.19 ± 0.06 nM (hFcRn, pH 7.4) KD = 11.9 nM (cyno FcRn, pH 7.4) KD = 0.87 ± 0.2 nM (hFcRn, pH 6.0) KD = 23.2 nM (cyno FcRn, pH 6.0) |
| Isotype | Human IgG4, κ |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein A purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | ELISA; IHC; Inhib; FuncS |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | FCGRT |
| Alternative Name | FCRN; alpha-chain; IgG receptor FcRn large subunit p51; Fc fragment of IgG, receptor, transporter, alpha; FcRn alpha chain; IgG Fc fragment receptor transporter alpha chain; heavy chain of the major histocompatibility complex class I-like Fc receptor; immunoglobulin receptor, intestinal, heavy chain; major histocompatibility complex class I-like Fc receptor; neonatal Fc receptor; neonatal Fc-receptor for Ig; transmembrane alpha chain of the neonatal receptor |
| Gene ID | 2217 |
| UniProt | P55899 |
| Research Area | Immunology |
