| Description | This product is an inhibitory antibody that specifically targets P. vivax PvDBPII. The antibody demonstrated strong growth inhibition in transgenic Plasmodium knowlesi assays of GIA. It also effectively blocked the binding of all five variant alleles of PvDBPII to DARC, indicating its ability to neutralize a diverse range of Plasmodium vivax variants. The epitope of the antibody is located within subdomain 3 of PvDBPII. Furthermore, the antibody successfully hindered reticulocyte invasion by all tested strains. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Plasmodium vivax |
| Isotype | Human IgG |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein A purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | ELISA; Inhib |
| Application Notes | We conducted assays to measure the growth inhibitory activity of the PvDBPOR line of transgenic Plasmodium knowlesi. In these assays, the mAb was present at a concentration of 25 μg/mL. |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | PvDBPII |
| Alternative Name | Plasmodium vivax Duffy binding protein Region II; PvDBP; Plasmodium vivax Duffy binding protein |
| Research Area | Microbiology |
