Conserved class 3 epitope site containing residues L335, V362 and P527.
ELISA; SPR; Neut
257 nM
Inquiry
V3S-0623-XY10
Receptor-binding domain (RBD)
ELISA, Neut
Inquiry
V3S-0623-XY101
Receptor-binding domain (RBD)
ELISA, Neut
0.33 nM
Inquiry
V3S-0623-XY102
Receptor-binding domain (RBD)
ELISA, Neut
5.9 nM
Inquiry
V3S-0623-XY106
Receptor-binding domain (RBD)
ELISA, Neut
2.37 nM
Inquiry
V3S-0623-XY112
The other side of the RBD, adjacent to the hACE2-binding site.
ELISA, Neut
Inquiry
V3S-0623-XY120
Receptor-binding domain (RBD)
ELISA, Neut
Inquiry
V3S-0623-XY122
Receptor-binding domain (RBD)
ELISA, Neut
Inquiry
V3S-0623-XY125
Receptor-binding domain (RBD)
ELISA, Neut
Inquiry
V3S-0623-XY126
Receptor-binding domain (RBD)
ELISA, Neut
Inquiry
V3S-0623-XY127
Receptor-binding domain (RBD)
ELISA, Neut
Inquiry
V3S-0623-XY128
Receptor-binding domain (RBD)
ELISA, Neut
Inquiry
V3S-0623-XY129
Receptor-binding domain (RBD)
ELISA, Neut
The antibody binds RBD with a KD of 0.2 nM as an IgG and 45.3 nM as a Fab.
Inquiry
V3S-0623-XY130
In the receptor-binding motif (RBM)
ELISA, Neut
Inquiry
V3S-0623-XY131
N343 glycan and helix region 364-371
ELISA, Neut
Inquiry
V3S-0623-XY134
Receptor-binding domain (RBD)
ELISA, Neut
Inquiry
V3S-0623-XY14
Receptor-binding domain (RBD)
ELISA, Neut
76.3 nM
Inquiry
V3S-0623-XY15
Receptor-binding domain (RBD)
ELISA, Neut
14.1 nM
Inquiry
V3S-0623-XY16
Receptor-binding domain (RBD)
ELISA, Neut
55.7 nM
Inquiry
V3S-0623-XY17
Receptor-binding domain (RBD)
ELISA, Neut
4.2 nM
Inquiry
V3S-0623-XY18
Overlaps with>90% of residues in the ACE2 RBM
ELISA, Neut
Inquiry
V3S-0623-XY19
Receptor-binding domain (RBD)
ELISA, Neut
Inquiry
V3S-0623-XY21
Receptor-binding domain (RBD)
ELISA, Neut
Inquiry
V3S-0623-XY24
Binds to the back of the "ridge" of RBD
ELISA, Neut
Inquiry
V3S-0623-XY26
Overlap receptor-binding site and inhibites RBD binding to human ACE2
ELISA, Neut
Inquiry
V3S-0623-XY27
Conserved RBD core
ELISA, Neut
Inquiry
V3S-0623-XY32
Receptor-binding domain (RBD)
ELISA, Neut
Inquiry
V3S-0623-XY34
Receptor-binding domain (RBD)
ELISA, Neut
Inquiry
V3S-0623-XY35
Receptor-binding domain (RBD)
ELISA, Neut
Inquiry
V3S-0623-XY36
Receptor-binding domain (RBD)
ELISA, Neut
Inquiry
V3S-0623-XY37
RBD receptor binding domain and overlapped with the hACE2 binding surface
ELISA, Neut
Inquiry
V3S-0623-XY39
A glycan-independent epitope
ELISA, Neut
Inquiry
V3S-0623-XY45
Receptor-binding domain (RBD)
ELISA, Neut
Inquiry
V3S-0623-XY49
Receptor-binding domain (RBD)
ELISA, Neut
Inquiry
V3S-0623-XY50
Receptor-binding domain (RBD)
ELISA, Neut
Inquiry
V3S-0623-XY54
ELISA, Neut
Inquiry
V3S-0623-XY57
Receptor-binding domain (RBD)
ELISA, Neut
23.3 nM
Inquiry
V3S-0623-XY6
Receptor-binding domain (RBD)
ELISA, Neut
The binding affinity of CR3022-B6 was 290 nM for soluble recombinant SARS-CoV-2 RBD.
Inquiry
V3S-0623-XY61
Receptor-binding domain (RBD)
ELISA, Neut
1.47 nM
Inquiry
V3S-0623-XY63
Receptor-binding domain (RBD)
ELISA, Neut
Inquiry
V3S-0623-XY65
Receptor-binding domain (RBD)
ELISA, Neut
2.15 nM
Inquiry
V3S-0623-XY67
Receptor-binding domain (RBD)
ELISA, Neut
3.28 nM
Inquiry
V3S-0623-XY68
Receptor-binding domain (RBD)
ELISA, Neut
1.95 nM
Inquiry
V3S-0623-XY69
Receptor-binding domain (RBD)
ELISA, Neut
0.24 nM
Inquiry
V3S-0623-XY7
An epitope distant from the ACE2 binding site.
ELISA, Neut
The binding affinity of CR3014-C8 was 61.1 nM.
Inquiry
V3S-0623-XY70
Receptor-binding domain (RBD)
ELISA, Neut
Inquiry
V3S-0623-XY71
Receptor-binding domain (RBD)
ELISA, Neut
The mAb showed a high affinity for both the SARS-CoV-2 S protein (0.55 nM) and for SARS-CoV-1 S protein (4.3 nM).
Inquiry
V3S-0623-XY72
Receptor binding motif (RBM)
ELISA, Neut
Inquiry
V3S-0623-XY74
Receptor-binding domain (RBD)
ELISA, Neut
Inquiry
V3S-0623-XY76
Receptor-binding domain (RBD)
ELISA, Neut
Inquiry
V3S-0623-XY78
Receptor-binding domain (RBD)
ELISA, Neut
Inquiry
V3S-0623-XY80
Receptor-binding domain (RBD)
ELISA, Neut
Inquiry
V3S-0623-XY83
Receptor-binding domain (RBD)
ELISA, Neut
Inquiry
V3S-0623-XY93
Receptor-binding domain (RBD)
ELISA, Neut
0.9 nM
Inquiry
V3S-0623-XY94
Receptor-binding domain (RBD)
ELISA, Neut
0.7 nM
Inquiry
V3S-0623-XY96
Receptor-binding domain (RBD)
ELISA, Neut
0.25 nM
Inquiry
V3S-0623-XY97
Receptor-binding domain (RBD)
ELISA, Neut
0.17 nM
Inquiry
V3S-0623-XY98
In the RBD domain and overlaps the ACE2 binding site.
ELISA, Neut
Inquiry
Summary
Property
Applications
Protocols
Target
Summary
Description
This antibody is a human IgG that binds Spike S1 protein of Severe acute respiratory syndrome coronavirus 2. The mAb bounds a unique epitope on the distal face of the RBD, a location consistent with an inability to inhibit ACE2 and RBD interaction in vitro.
Clonality
Monoclonal
Host Species
Human
Target Species
SARS-CoV-2
Epitope
Distal face of the RBD
Property
Expression Species
HEK293F or CHO cell line
Conjugation
Unconjugated
Purity
>95%
Endotoxin
<1 EU/mg
Form
Liquid
Purification
Protein A purified
Sterility
0.2 μM filtered
Formulation
PBS, pH 7.4
Preservation
No preservatives
Stabilizer
No stabilizers
Storage
Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics.
Applications
Application
ELISA; BLI
Application Notes
ELISA: 5 μg/mL with a serial 1:2.5 dilution Bio-layer interferometry (BLI): 5 μg/mL
