ZIKV E (aa 220-366) Specific Recomb™ Antibody (V3S-0923-CJ36), Chicken IgY (CAT#: V3S-0923-CJ36)

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Virus Background


Description This chicken anti-ZIKV E IgY antibody (clone ZIKVEF2L07) recognizes recombinant ZIKV E proteins. The ZIKVEF2L07 showed antigen recognition against truncated protein fragment 3 (F3, aa 220-366).
Clonality Monoclonal
Host Species Chicken
Target Species Zika virus (ZIKV)
Immunogen ZIKV E recombinant proteins with His-tag
Epitope aa 220-366 from ZIKV E protein.
Affinity KD = 1.49 × 10−5 M
Function Envelope protein E:
Binds to host cell surface receptors and mediates fusion between viral and cellular membranes. Efficient virus attachment to cell is, at least in part, mediated by host HAVCR1 in a cell-type specific manner.
In addition, host NCAM1 can also be used as entry receptor.
Interaction with host HSPA5 plays an important role in the early stages of infection as well.
Envelope protein is synthesized in the endoplasmic reticulum and forms a heterodimer with protein prM. The heterodimer plays a role in virion budding in the ER, and the newly formed immature particle is covered with 60 spikes composed of heterodimers between precursor prM and envelope protein E. The virion is transported to the Golgi apparatus where the low pH causes the dissociation of PrM-E heterodimers and formation of E homodimers. PrM-E cleavage is inefficient, many virions are only partially matured and immature prM-E proteins could play a role in immune evasion.
Isotype Chicken IgY


Expression Species HEK293F or CHO cell line
Conjugation Unconjugated
Purity >95%
Endotoxin <1 EU/mg
Form Liquid
Sterility 0.2 μM filtered
Formulation PBS, pH 7.4
Preservation No preservatives
Stabilizer No stabilizers
Storage Store at 4°C within a week. For longer storage, aliquot and store at -20°C.


Application WB
Application Notes A non-reactivity pattern of ZIKVEF3S07 to ZIKV_E F2 ( aa 1-251). ZIKVEF3S07 could not recognize the ZIKV_E protein expressed by monkey kidney cells and is not suitable for flow cytometry.


ELISA Enzyme-Linked Immunosorbent Assay Protocol
WB Western Blot Protocol
FC Flow Cytometry Protocol


Target ZIKV E
Alternative Name ZIKV_gp1
Gene ID 7751225
Research Area Microbiology
Related Disease Meningoencephalitis; Myelitis; Guillain-Barré syndrome; Microcephaly

Virus Background

Post Translational Modification Envelope protein E:
N-glycosylation plays a role in virulence in mammalian and mosquito hosts, but may have no effect on neurovirulence.
Ubiquitination by host TRIM7 promotes virus attachment and fusion of the virus and the host endosome membrane.
For research use only, not directly for clinical use.
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