CD27 Specific Neutra™ Antibody Products

Product list

CD27 molecule (CD27), also known as TNFRSF7 or Tp55, is a single-pass type I membrane protein overexpressed in lymphoid tissues such as the spleen and peripheral blood mononuclear cells. As an essential receptor for T-cell immunity, membrane-bound CD27 binds to the ligand CD70 and plays a key role in regulating cellular anti-tumor immunity. Soluble CD27 also has effects on T cell activation and its expression level is considered as a biomarker of immune responses.

Its Gene ID: 939, UniProtKB ID: P26824, and OMIM ID: 186711.

Functions of the CD27-CD70 Signaling Pathway

TLR- and CD40-induced expression of CD70 regulates the CD27-CD70 interaction and stimulates the NF-κB, JNK, PI3K, and MEK signaling pathways. The signal transduction may have the functions listed below (figure 1).

  • Regulates activation of B cells and immunoglobulin synthesis.
  • Promotes activation of T cells and their differentiation into T helper 1 cells.
  • Transduction of costimulatory signals with TCR engagement.

Fig.1 CD27-CD70 pathway in immune regulation. (Han, et al., 2016)Fig.1 CD27-CD70 pathway in immune regulation.1

The Role of the CD27-CD70 Pathway in Immune Evasion

The CD27-CD70 axis has bidirectional functional immune effects and may retrograde anti-tumor signals. As shown in Figure 2, the axis facilitates immune evasion and suppression of solid tumor cells and subsequently promotes tumor migration and invasion in the following ways:

  • Increases survival, proliferation, and infiltration of regulatory T cells.
  • Promotes T cell exhaustion and apoptosis.
  • Enhances NK cell exhaustion.
  • Recruits or activates tumor-associated macrophages (TAMs).

Fig.2 The CD70-CD27 axis in the tumor microenvironment. (Flieswasser, et al., 2022)Fig.2 The CD70-CD27 axis in the tumor microenvironment.2

CD27 in Anti-tumor Immunotherapies

CD27 has been implicated in many novel anti-cancer studies. With a relatively comprehensive understanding of the CD70-CD27 signaling axis, CD27-related biological products could be used in many treatment strategies:

  • Development of agonistic monoclonal antibodies for potential therapy of CD27 overexpressing lymphoma and leukemia.
  • Administration along with anti-PD-1/PDL1 therapy in solid tumors.
  • Implementation of CD27 in chimeric antigen receptor T cells (CAR-T) for optimal cell immunotherapy.

Creative Biolabs offers more than fifty anti-CD27 antibodies for twelve applications such as enzyme-linked immunosorbent assay, flow cytometry, and neutralization.

REFERENCES

  1. Han, et al. "The CD27-CD70 pathway and pathogenesis of autoimmune disease." Seminars in arthritis and rheumatism. Vol. 45. No. 4. WB Saunders, 2016.
  2. Flieswasser, Tal, et al. "The CD70-CD27 axis in oncology: the new kids on the block." Journal of experimental & clinical cancer research 41.1 (2022): 1-15.
Show More Close

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0622-YC1245) (CAT#: V3S-0622-YC1245)

Target: CD27

Host Species: Human

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0622-YC1246) (CAT#: V3S-0622-YC1246)

Target: CD27

Host Species: Human

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0622-YC1247) (CAT#: V3S-0622-YC1247)

Target: CD27

Host Species: Human

Target Species: Human,

Application: ELISA,

Inquiry

Anti-CD27 Neutralizing Antibody (V3S-0622-YC1248) (CAT#: V3S-0622-YC1248)

Target: CD27

Host Species: Human

Target Species: Human,

Application: FuncS,

Inquiry

Anti-CD27 Neutralizing Antibody (V3S-0622-YC4315) (CAT#: V3S-0622-YC4315)

Target: CD27

Host Species: Human

Target Species: Human,

Application: ELISA,IP,FC,FuncS,Neut,IF,ICC,

Inquiry

Recombinant Anti-CD27 (N-terminus) Antibody (V3S-0522-YC932) (CAT#: V3S-0522-YC932)

Target: CD27

Host Species: Human

Target Species: Human,

Application: ELISA,FC,

Inquiry

Anti-CD27 (CRD2 domain) Neutralizing Antibody (V3S-0522-YC1009) (CAT#: V3S-0522-YC1009)

Target: CD27

Host Species: Human

Target Species: Human, Monkey,

Application: ELISA,FC,Neut,FuncS,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC3104) (CAT#: V3S-0522-YC3104)

Target: CD27

Host Species: Human

Target Species: Human, Cynomolgus,

Application: ELISA,FC,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5149) (CAT#: V3S-0522-YC5149)

Target: CD27

Host Species: Rat

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5150) (CAT#: V3S-0522-YC5150)

Target: CD27

Host Species: Rat

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5151) (CAT#: V3S-0522-YC5151)

Target: CD27

Host Species: Rat

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5152) (CAT#: V3S-0522-YC5152)

Target: CD27

Host Species: Rat

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5153) (CAT#: V3S-0522-YC5153)

Target: CD27

Host Species: Rat

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5154) (CAT#: V3S-0522-YC5154)

Target: CD27

Host Species: Human

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5155) (CAT#: V3S-0522-YC5155)

Target: CD27

Host Species: Human

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5156) (CAT#: V3S-0522-YC5156)

Target: CD27

Host Species: Human

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5157) (CAT#: V3S-0522-YC5157)

Target: CD27

Host Species: Human

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5158) (CAT#: V3S-0522-YC5158)

Target: CD27

Host Species: Mouse

Target Species: Human,

Application: SPR,FC,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5159) (CAT#: V3S-0522-YC5159)

Target: CD27

Host Species: Mouse

Target Species: Human,

Application: SPR,FC,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5160) (CAT#: V3S-0522-YC5160)

Target: CD27

Host Species: Mouse

Target Species: Human,

Application: SPR,FC,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5161) (CAT#: V3S-0522-YC5161)

Target: CD27

Host Species: Mouse

Target Species: Human,

Application: SPR,FC,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5162) (CAT#: V3S-0522-YC5162)

Target: CD27

Host Species: Mouse

Target Species: Human,

Application: SPR,FC,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5163) (CAT#: V3S-0522-YC5163)

Target: CD27

Host Species: Mouse

Target Species: Human,

Application: SPR,FC,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5164) (CAT#: V3S-0522-YC5164)

Target: CD27

Host Species: Human

Target Species: Human,

Application: SPR,FC,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5165) (CAT#: V3S-0522-YC5165)

Target: CD27

Host Species: Human

Target Species: Human,

Application: SPR,FC,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5167) (CAT#: V3S-0522-YC5167)

Target: CD27

Host Species: Human

Target Species: Human,

Application: SPR,FC,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5168) (CAT#: V3S-0522-YC5168)

Target: CD27

Host Species: Human

Target Species: Human,

Application: SPR,FC,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5169) (CAT#: V3S-0522-YC5169)

Target: CD27

Host Species: Human

Target Species: Human,

Application: SPR,FC,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5170) (CAT#: V3S-0522-YC5170)

Target: CD27

Host Species: Human

Target Species: Human,

Application: SPR,FC,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5171) (CAT#: V3S-0522-YC5171)

Target: CD27

Host Species: Human

Target Species: Human,

Application: SPR,FC,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5172) (CAT#: V3S-0522-YC5172)

Target: CD27

Host Species: Human

Target Species: Human,

Application: SPR,FC,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5173) (CAT#: V3S-0522-YC5173)

Target: CD27

Host Species: Human

Target Species: Human,

Application: SPR,FC,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5178) (CAT#: V3S-0522-YC5178)

Target: CD27

Host Species: Mouse

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5179) (CAT#: V3S-0522-YC5179)

Target: CD27

Host Species: Mouse

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5180) (CAT#: V3S-0522-YC5180)

Target: CD27

Host Species: Mouse

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5181) (CAT#: V3S-0522-YC5181)

Target: CD27

Host Species: Mouse

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5182) (CAT#: V3S-0522-YC5182)

Target: CD27

Host Species: Human

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5183) (CAT#: V3S-0522-YC5183)

Target: CD27

Host Species: Human

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5184) (CAT#: V3S-0522-YC5184)

Target: CD27

Host Species: Human

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5185) (CAT#: V3S-0522-YC5185)

Target: CD27

Host Species: Human

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5186) (CAT#: V3S-0522-YC5186)

Target: CD27

Host Species: Human

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5187) (CAT#: V3S-0522-YC5187)

Target: CD27

Host Species: Human

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5188) (CAT#: V3S-0522-YC5188)

Target: CD27

Host Species: Human

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5189) (CAT#: V3S-0522-YC5189)

Target: CD27

Host Species: Human

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5190) (CAT#: V3S-0522-YC5190)

Target: CD27

Host Species: Human

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5191) (CAT#: V3S-0522-YC5191)

Target: CD27

Host Species: Human

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5192) (CAT#: V3S-0522-YC5192)

Target: CD27

Host Species: Human

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5193) (CAT#: V3S-0522-YC5193)

Target: CD27

Host Species: Human

Target Species: Human,

Application: ELISA,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5194) (CAT#: V3S-0522-YC5194)

Target: CD27

Host Species: Rat

Target Species: Mouse,

Application: FC,

Inquiry

Recombinant Anti-CD27 Antibody (V3S-0522-YC5195) (CAT#: V3S-0522-YC5195)

Target: CD27

Host Species: Mouse

Target Species: Human,

Application: ELISA,

For research use only, not directly for clinical use.


banner banner
© 2024 Creative Biolabs. All Rights Reserved.
antibody
ISO 9001 Certified - Creative Biolabs Quality Management System.
Online Inquiry