CD27 molecule (CD27), also known as TNFRSF7 or Tp55, is a single-pass type I membrane protein overexpressed in lymphoid tissues such as the spleen and peripheral blood mononuclear cells. As an essential receptor for T-cell immunity, membrane-bound CD27 binds to the ligand CD70 and plays a key role in regulating cellular anti-tumor immunity. Soluble CD27 also has effects on T cell activation and its expression level is considered as a biomarker of immune responses.
Its Gene ID: 939, UniProtKB ID: P26824, and OMIM ID: 186711.
TLR- and CD40-induced expression of CD70 regulates the CD27-CD70 interaction and stimulates the NF-κB, JNK, PI3K, and MEK signaling pathways. The signal transduction may have the functions listed below (figure 1).
Fig.1 CD27-CD70 pathway in immune regulation.1
The CD27-CD70 axis has bidirectional functional immune effects and may retrograde anti-tumor signals. As shown in Figure 2, the axis facilitates immune evasion and suppression of solid tumor cells and subsequently promotes tumor migration and invasion in the following ways:
Fig.2 The CD70-CD27 axis in the tumor microenvironment.2
CD27 has been implicated in many novel anti-cancer studies. With a relatively comprehensive understanding of the CD70-CD27 signaling axis, CD27-related biological products could be used in many treatment strategies:
Creative Biolabs offers more than fifty anti-CD27 antibodies for twelve applications such as enzyme-linked immunosorbent assay, flow cytometry, and neutralization.
Recombinant Anti-CD27 Antibody (V3S-0622-YC1245) (CAT#: V3S-0622-YC1245)
Target: CD27
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD27 Antibody (V3S-0622-YC1246) (CAT#: V3S-0622-YC1246)
Target: CD27
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD27 Antibody (V3S-0622-YC1247) (CAT#: V3S-0622-YC1247)
Target: CD27
Host Species: Human
Target Species: Human,
Application: ELISA,
Anti-CD27 Neutralizing Antibody (V3S-0622-YC1248) (CAT#: V3S-0622-YC1248)
Target: CD27
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-CD27 Neutralizing Antibody (V3S-0622-YC4315) (CAT#: V3S-0622-YC4315)
Target: CD27
Host Species: Human
Target Species: Human,
Application: ELISA,IP,FC,FuncS,Neut,IF,ICC,
Recombinant Anti-CD27 (N-terminus) Antibody (V3S-0522-YC932) (CAT#: V3S-0522-YC932)
Target: CD27
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Anti-CD27 (CRD2 domain) Neutralizing Antibody (V3S-0522-YC1009) (CAT#: V3S-0522-YC1009)
Target: CD27
Host Species: Human
Target Species: Human, Monkey,
Application: ELISA,FC,Neut,FuncS,
Recombinant Anti-CD27 Antibody (V3S-0522-YC3104) (CAT#: V3S-0522-YC3104)
Target: CD27
Host Species: Human
Target Species: Human, Cynomolgus,
Application: ELISA,FC,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5149) (CAT#: V3S-0522-YC5149)
Target: CD27
Host Species: Rat
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5150) (CAT#: V3S-0522-YC5150)
Target: CD27
Host Species: Rat
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5151) (CAT#: V3S-0522-YC5151)
Target: CD27
Host Species: Rat
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5152) (CAT#: V3S-0522-YC5152)
Target: CD27
Host Species: Rat
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5153) (CAT#: V3S-0522-YC5153)
Target: CD27
Host Species: Rat
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5154) (CAT#: V3S-0522-YC5154)
Target: CD27
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5155) (CAT#: V3S-0522-YC5155)
Target: CD27
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5156) (CAT#: V3S-0522-YC5156)
Target: CD27
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5157) (CAT#: V3S-0522-YC5157)
Target: CD27
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5158) (CAT#: V3S-0522-YC5158)
Target: CD27
Host Species: Mouse
Target Species: Human,
Application: SPR,FC,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5159) (CAT#: V3S-0522-YC5159)
Target: CD27
Host Species: Mouse
Target Species: Human,
Application: SPR,FC,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5160) (CAT#: V3S-0522-YC5160)
Target: CD27
Host Species: Mouse
Target Species: Human,
Application: SPR,FC,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5161) (CAT#: V3S-0522-YC5161)
Target: CD27
Host Species: Mouse
Target Species: Human,
Application: SPR,FC,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5162) (CAT#: V3S-0522-YC5162)
Target: CD27
Host Species: Mouse
Target Species: Human,
Application: SPR,FC,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5163) (CAT#: V3S-0522-YC5163)
Target: CD27
Host Species: Mouse
Target Species: Human,
Application: SPR,FC,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5164) (CAT#: V3S-0522-YC5164)
Target: CD27
Host Species: Human
Target Species: Human,
Application: SPR,FC,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5165) (CAT#: V3S-0522-YC5165)
Target: CD27
Host Species: Human
Target Species: Human,
Application: SPR,FC,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5167) (CAT#: V3S-0522-YC5167)
Target: CD27
Host Species: Human
Target Species: Human,
Application: SPR,FC,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5168) (CAT#: V3S-0522-YC5168)
Target: CD27
Host Species: Human
Target Species: Human,
Application: SPR,FC,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5169) (CAT#: V3S-0522-YC5169)
Target: CD27
Host Species: Human
Target Species: Human,
Application: SPR,FC,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5170) (CAT#: V3S-0522-YC5170)
Target: CD27
Host Species: Human
Target Species: Human,
Application: SPR,FC,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5171) (CAT#: V3S-0522-YC5171)
Target: CD27
Host Species: Human
Target Species: Human,
Application: SPR,FC,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5172) (CAT#: V3S-0522-YC5172)
Target: CD27
Host Species: Human
Target Species: Human,
Application: SPR,FC,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5173) (CAT#: V3S-0522-YC5173)
Target: CD27
Host Species: Human
Target Species: Human,
Application: SPR,FC,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5178) (CAT#: V3S-0522-YC5178)
Target: CD27
Host Species: Mouse
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5179) (CAT#: V3S-0522-YC5179)
Target: CD27
Host Species: Mouse
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5180) (CAT#: V3S-0522-YC5180)
Target: CD27
Host Species: Mouse
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5181) (CAT#: V3S-0522-YC5181)
Target: CD27
Host Species: Mouse
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5182) (CAT#: V3S-0522-YC5182)
Target: CD27
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5183) (CAT#: V3S-0522-YC5183)
Target: CD27
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5184) (CAT#: V3S-0522-YC5184)
Target: CD27
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5185) (CAT#: V3S-0522-YC5185)
Target: CD27
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5186) (CAT#: V3S-0522-YC5186)
Target: CD27
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5187) (CAT#: V3S-0522-YC5187)
Target: CD27
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5188) (CAT#: V3S-0522-YC5188)
Target: CD27
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5189) (CAT#: V3S-0522-YC5189)
Target: CD27
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5190) (CAT#: V3S-0522-YC5190)
Target: CD27
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5191) (CAT#: V3S-0522-YC5191)
Target: CD27
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5192) (CAT#: V3S-0522-YC5192)
Target: CD27
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5193) (CAT#: V3S-0522-YC5193)
Target: CD27
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5194) (CAT#: V3S-0522-YC5194)
Target: CD27
Host Species: Rat
Target Species: Mouse,
Application: FC,
Recombinant Anti-CD27 Antibody (V3S-0522-YC5195) (CAT#: V3S-0522-YC5195)
Target: CD27
Host Species: Mouse
Target Species: Human,
Application: ELISA,