CTLA4 Specific NeutraTM Antibody Products
Product listBasic Information
Cytotoxic T-lymphocyte associated protein 4 (CTLA4), also known as CD152, encodes the ligand for the B7 family costimulatory proteins CD80 and CD86. CTLA4 is an immune checkpoint protein expressed primarily on the cell surface of T-cells. As a CD molecule, CTLA4 is widely distributed in lymphoid tissues, where it is found at the highest levels. It triggers an inhibitory signal to T cells to affect the T-cell immune responses.
Its Gene ID is 1493, UniProtKB ID is P16410, and OMIM ID is 123890.
Function
Functions for CTLA4 include:
- CTLA4 is associated with autoimmune diseases.
- CTLA4 is a key negative regulator of T-cell homeostasis and self-tolerance.
Signal Pathway in T Cells
T cells are regulated when TCRs bind to the antigen on APCs in concert with CD28/CTLA-4:B7-mediated regulatory signals. As shown in Fig.1, the relative amount of B7 binding to CD28 and CTLA-4 may determine the outcomes of T-cell regulation, i.e., whether they will be activated or inhibited.
Fig. 1 CTLA-4-mediated inhibition of T cells.1
Drug Development
The CTLA4 pathway has significant momentum in the therapeutic application of autoimmunity and cancer immunotherapy.
Antibodies that block CTLA-4 are now approved or in development for other cancers, as listed in Table 1. The combination strategy with PD-1/PDL1 pathways could lead to increased therapeutic efficacy.
Table 1 CTLA-4 inhibitors approved or in clinical trials.1
Antibody Validation
Anti-CTLA4 monoclonal antibodies at Creative Biolabs have a wide range of applications, and there is always one for our customers. In addition, our antibody production is routinely subjected to strict quality control, so they could be used without hesitation.
REFERENCE
- Buchbinder, Elizabeth I, and Anupam Desai. "CTLA-4 and PD-1 Pathways: Similarities, Differences, and Implications of Their Inhibition." American journal of clinical oncology vol. 39,1 (2016): 98-106.
