DNA Specific Neutra™ Antibody Products
Product listAccelerate Your Research and Development!
Are you currently facing challenges in autoimmune disease diagnostics, biomarker discovery, or the development of highly specific research tools? At Creative Biolabs, our DNA Specific Antibody Products offer unparalleled precision and reliability, providing critical solutions for your most demanding projects in autoimmune research and diagnostics. We deliver highly characterized antibodies and comprehensive support to ensure your success.
Contact our team to get an inquiry now!
Introduction of DNA
Deoxyribonucleic acid (DNA) is the fundamental molecule of life, carrying the genetic instructions essential for the development, functioning, growth, and reproduction of all known organisms. First isolated in 1869 and structurally elucidated through Watson-Crick's 1953 double helix model, DNA plays a central role in genetic transmission and protein biosynthesis. Structurally, DNA is a polymer composed of two antiparallel polynucleotide chains, each made of nucleotides containing a deoxyribose sugar, a phosphate group, and one of four nitrogenous bases: adenine (A), guanine (G), cytosine (C), or thymine (T). The specific pairing of A with T and C with G via hydrogen bonds forms the stable double helix, which is crucial for its ability to replicate and serve as a template for RNA synthesis.
DNA's biological functions extend beyond simple genetic storage. It forms the basis of genes and genomes, dictating the blueprint of life. The processes of transcription (DNA to RNA) and translation (RNA to protein) are central to cellular function, while DNA replication ensures the faithful transmission of genetic information during cell division. Disruptions in DNA integrity or its recognition by the immune system can lead to various diseases. In certain autoimmune conditions, the body's immune system erroneously produces antibodies that target its own DNA, leading to significant clinical implications. Understanding these interactions is critical for both basic research and the development of diagnostic and therapeutic strategies.
Fig. 1 DNA Structure.Distributed under CC BY-SA 4.0, from Wiki, without modification
Antibodies Against DNA
Antibodies against DNA, particularly anti-double-stranded DNA (anti-dsDNA) antibodies, are a hallmark of Systemic Lupus Erythematosus (SLE), a complex autoimmune disease. These autoantibodies are highly specific markers for SLE, playing a crucial role in diagnosis and monitoring disease activity, especially in conditions like lupus nephritis. While their presence is a strong indicator of SLE, their levels can fluctuate with disease activity, making them valuable biomarkers for tracking disease progression and treatment response.
Fig. 2 The Production of anti-DNA scFvs.1
Creative Biolabs’ DNA Specific Antibody Products are meticulously developed and validated to detect and characterize these critical autoantibodies with high precision. Our product range includes antibodies specifically targeting double-stranded DNA (dsDNA) and single-stranded DNA (ssDNA), offering versatile tools for various applications:
- Diagnostic Assays: Our anti-dsDNA antibodies are ideal for developing and optimizing highly sensitive and specific diagnostic kits (e.g., ELISA, CLIFT) for SLE and other autoimmune conditions. They provide reliable detection of circulating autoantibodies in patient samples, aiding in accurate diagnosis and differential diagnosis.
- Research Tools: These antibodies serve as invaluable reagents for investigating the pathogenesis of autoimmune diseases, studying the molecular mechanisms of DNA-antibody interactions, and identifying novel biomarkers. They can be used in immunofluorescence, Western blotting, and immunoprecipitation assays to explore cellular and molecular targets.
- Therapeutic Development: Understanding the specificity and cross-reactivity of anti-DNA antibodies, as highlighted by research into their interaction with pyrrolated proteins, can inform the development of targeted therapeutic interventions for SLE. Our antibodies can assist in screening and validating potential drug candidates that modulate these autoimmune responses.
By providing highly characterized and reliable DNA specific antibodies, Creative Biolabs empowers researchers and diagnostic developers to achieve accurate, reproducible, and impactful results in the challenging field of autoimmune disease.
Why Choose Us?
Creative Biolabs pioneers precision-engineered DNA-targeting antibody solutions: Our commitment to your success is built upon several key advantages:
- Scientific Excellence: We are dedicated to the highest scientific standards in antibody development and production.
- Unparalleled Specificity: Our products are rigorously tested to ensure precise binding to DNA, minimizing cross-reactivity.
- Robust Performance: Experience consistent and reliable results across various applications.
- Proven Expertise: Leverage decades of specialization and technical mastery.
- Cutting-Edge Methodologies: We leverage the latest technologies and innovative approaches in antibody engineering and validation.
- Reliable Tools: We ensure you receive the most dependable tools for your critical research and diagnostic needs.
FAQs
Here are some common questions potential customers have about Creative Biolabs’ DNA Specific Antibody Products:
Q: How do Creative Biolabs’ DNA Specific Antibody Products ensure high specificity compared to other options on the market?
A: Our DNA Specific Antibody Products undergo rigorous purification and validation processes, including extensive cross-reactivity testing against various nuclear antigens and non-specific DNA sequences. We utilize advanced immunoassay techniques and multiple validation platforms to confirm their precise binding to DNA, minimizing off-target interactions. This meticulous approach ensures the high specificity crucial for accurate research and diagnostic outcomes.
Q: What applications are these antibodies suitable for, and can they be used in both research and clinical settings?
A: Creative Biolabs’ DNA Specific Antibody Products are highly versatile and suitable for a broad range of applications, including ELISA, Western Blotting, Immunofluorescence, and flow cytometry. They are designed to meet the stringent requirements of both basic scientific research into autoimmune mechanisms and the development of clinical diagnostic assays for conditions like Systemic Lupus Erythematosus (SLE).
Q: What advantages do Creative Biolabs’ DNA specific antibodies offer in terms of sensitivity for detecting low-level autoantibodies?
A: Our antibodies are developed and optimized for exceptional sensitivity, enabling the detection of even low concentrations of DNA autoantibodies, which is critical for early diagnosis and monitoring of disease activity. This high sensitivity is achieved through optimized antibody affinity and robust assay compatibility, providing reliable results even with challenging samples.
Access the Creative Biolabs Edge – Request Your Quote Now
REFERENCES
- Anan, Yusuke et al. “Molecular and structural basis of anti-DNA antibody specificity for pyrrolated proteins.” Communications biology vol. 7,1 149. 3 Feb. 2024, DOI:10.1038/s42003-024-05851-0. Distributed under Open Access license CC BY 4.0, without modification.
