ERBB3, also known as The Human Epidermal Growth Factor Receptor3 (HER3), constitutes a member of the receptor tyrosine kinase family, playing pivotal roles in the biological processes of both normal and tumor cells. The HER family receptors consist of extracellular ligand-binding domains, transmembrane domains, intracellular kinase domains, and C-terminal tails.
The ERBB3 gene is located on the long arm of human chromosome 12, encoding a 180 kDa protein. Its extracellular domain comprises four subdomains, with subdomains I and III responsible for ligand binding, while subdomains II and IV are rich in cysteine residues. HER3 exhibits widespread expression in various human tissues, including the gastrointestinal tract, urinary tract, respiratory tract, reproductive tract, skin, endocrine, and nervous system cells.
Fig.1 Structure and activation of HER receptors.1
ERBB3 stands as a unique member of the EGFR family, possessing little to no intrinsic intracellular tyrosine kinase activity. However, divergence exists among key residues in the kinase domain of ERBB3, leading to its adoption of a conformation resembling an inactive state. Activation of ERBB3 through neuregulin interactions initiates the PI3K/AKT and MAPK signaling pathways, fostering cellular proliferation.
Fig.2 HER receptor signaling.2
ERBB3 is expressed in various cancers and is closely associated with tumorigenesis, tumor progression, and drug resistance. While ERBB3 alone may not initiate tumorigenesis, its dimerization with other EGFR family members (such as HER2) may contribute to tumor development. Furthermore, ERBB3 expression levels correlate with disease advancement and/or unfavorable prognoses across various cancer types, encompassing breast, colorectal, gastric, lung, skin, and pancreatic cancers.
Fig.3 Therapeutic strategies targeting HER3.2
At Creative Biolabs, we offer a range of antibody services related to targets to support clients' research and drug development projects. With advanced neutralizing antibody and recombinant antibody technology platforms, we efficiently produce target-related antibody proteins for biological functional studies and drug screening. Our well-designed and characterized antibody product library also provides comprehensive and customizable research tools for your needs.
Please do not hesitate to contact us for any demands.
Recombinant Anti-ERBB3 (S1 domain) Neutralizing Antibody (V3S-0622-YC159) (CAT#: V3S-0622-YC159)
Target: ERBB3
Host Species: Human
Target Species: Human, Rat,
Application: ELISA,FC,Inhib,FuncS,
Recombinant Anti-ERBB3 (ECD domain) Neutralizing Antibody (V3S-0622-YC160) (CAT#: V3S-0622-YC160)
Target: ERBB3
Host Species: Mouse
Target Species: Human,
Application: ELISA,FC,IHC,Inhib,IP,WB,FuncS,
Recombinant Anti-ERBB3 (ECD domain) Neutralizing Antibody (V3S-0622-YC161) (CAT#: V3S-0622-YC161)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: ELISA,FC,IHC,Inhib,IP,WB,FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1503) (CAT#: V3S-0622-YC1503)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1504) (CAT#: V3S-0622-YC1504)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1505) (CAT#: V3S-0622-YC1505)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1506) (CAT#: V3S-0622-YC1506)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1507) (CAT#: V3S-0622-YC1507)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1508) (CAT#: V3S-0622-YC1508)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1509) (CAT#: V3S-0622-YC1509)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1510) (CAT#: V3S-0622-YC1510)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1511) (CAT#: V3S-0622-YC1511)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1512) (CAT#: V3S-0622-YC1512)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1513) (CAT#: V3S-0622-YC1513)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1514) (CAT#: V3S-0622-YC1514)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1515) (CAT#: V3S-0622-YC1515)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1516) (CAT#: V3S-0622-YC1516)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1517) (CAT#: V3S-0622-YC1517)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1518) (CAT#: V3S-0622-YC1518)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1519) (CAT#: V3S-0622-YC1519)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1520) (CAT#: V3S-0622-YC1520)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1521) (CAT#: V3S-0622-YC1521)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1522) (CAT#: V3S-0622-YC1522)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1523) (CAT#: V3S-0622-YC1523)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1524) (CAT#: V3S-0622-YC1524)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1525) (CAT#: V3S-0622-YC1525)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1526) (CAT#: V3S-0622-YC1526)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1527) (CAT#: V3S-0622-YC1527)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1528) (CAT#: V3S-0622-YC1528)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1529) (CAT#: V3S-0622-YC1529)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1530) (CAT#: V3S-0622-YC1530)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1531) (CAT#: V3S-0622-YC1531)
Target: ERBB3
Host Species: Mouse
Target Species: Human,
Application: FuncS,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1532) (CAT#: V3S-0622-YC1532)
Target: ERBB3
Host Species: Mouse
Target Species: Human,
Application: FuncS,
Anti-ERBB3 (ECD domian) Neutralizing Antibody (V3S-0622-YC1533) (CAT#: V3S-0622-YC1533)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: Inhib,ELISA,
Anti-ERBB3 (ECD domain) Neutralizing Antibody (V3S-0622-YC1534) (CAT#: V3S-0622-YC1534)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: WB,ELISA,Inhib,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1535) (CAT#: V3S-0622-YC1535)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: WB,ELISA,Inhib,FC,
Anti-ERBB3 (aa 1-643) Neutralizing Antibody (V3S-0622-YC1536) (CAT#: V3S-0622-YC1536)
Target: ERBB3
Host Species: Rabbit
Target Species: Human,
Application: Inhib,ELISA,
Anti-ERBB3 (aa 1-643) Neutralizing Antibody (V3S-0622-YC1537) (CAT#: V3S-0622-YC1537)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: Inhib,ELISA,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1538) (CAT#: V3S-0622-YC1538)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: ELISA,Inhib,FC,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1539) (CAT#: V3S-0622-YC1539)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: ELISA,Inhib,FC,
Recombinant Anti-ERBB3 Antibody (V3S-0622-YC1540) (CAT#: V3S-0622-YC1540)
Target: ERBB3
Host Species: Mouse
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-ERBB3 Antibody (V3S-0622-YC1541) (CAT#: V3S-0622-YC1541)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1542) (CAT#: V3S-0622-YC1542)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: ELISA,Inhib,FC,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1543) (CAT#: V3S-0622-YC1543)
Target: ERBB3
Host Species: Mouse
Target Species: Human,
Application: ELISA,Inhib,FC,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1544) (CAT#: V3S-0622-YC1544)
Target: ERBB3
Host Species: Mouse
Target Species: Human,
Application: ELISA,Inhib,FC,WB,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1545) (CAT#: V3S-0622-YC1545)
Target: ERBB3
Host Species: Mouse
Target Species: Human,
Application: ELISA,Inhib,FC,
Anti-ERBB3 Neutralizing Antibody (V3S-0622-YC1546) (CAT#: V3S-0622-YC1546)
Target: ERBB3
Host Species: Mouse
Target Species: Human,
Application: IF,Inhib,FC,
Anti-ERBB3 (ECD domain) Neutralizing Antibody (V3S-0622-YC1547) (CAT#: V3S-0622-YC1547)
Target: ERBB3
Host Species: Mouse
Target Species: Human,
Application: ELISA,Inhib,FC,
Recombinant Anti-ERBB3 Antibody (V3S-0622-YC3256) (CAT#: V3S-0622-YC3256)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-ERBB3 Antibody (V3S-0622-YC3257) (CAT#: V3S-0622-YC3257)
Target: ERBB3
Host Species: Human
Target Species: Human,
Application: ELISA,
