growth differentiation factor 5

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Gdf5 is a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates the development of numerous tissue and cell types, including cartilage, joints, brown fat, teeth, and the growth of neuronal axons and dendrites. Mice with a mutation in this gene exhibit enhanced tooth enamel formation.

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Anti-Gdf5 Neutralizing Antibody (V3S-0822-YC1230) (CAT#: V3S-0822-YC1230)

Target: Gdf5

Host Species: Rat

Target Species: Mouse,

Application: Neut,WB,