GNRH1 encodes a preproprotein that is proteolytically processed to generate a peptide that is a member of the GnRH (gonadotropin-releasing hormone) family of peptides. Alternative splicing results in multiple transcript variants, at least one of which is secreted and then cleaved to generate gonadoliberin-1 and GnRH-associated peptide 1. Gonadoliberin-1 stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutations in GNRH1 are associated with hypogonadotropic hypogonadism.