Hepatitis A Virus Cellular Receptor 2 (HAVCR2), also known as TIM-3 and CD366, encodes a cell surface protein that interacts with ligands such as LGALS9, HMGB1, and phosphatidylserine. As a CD molecule and an immune checkpoint protein, it is expressed primarily in CD4+ Th cells, CD8+ Tc cells, and innate immune cells. By binding to ligands, HAVCR2 transmits the inhibitory signal in autoimmune and alloimmune responses.
Its Gene ID is 84868, UniProtKB ID is Q8TDQ0, and OMIM ID is 606652.
Functions for HAVCR2 include:
The binding of Bat-3 to the cytoplasmic tail of HAVCR2 (Tim-3), triggers the activation of T cells, which are then able to promote T-cell proliferation and survival. The ligation of HAVCR2, which displaces Bat-3 from the tail, downregulates TCR signaling and suppresses the proliferation and survival of T cells.
Fig.1 HAVCR2 (Tim-3) signaling in T cells.1
As an antibody target, HAVCR2 and its inhibitory signaling pathway have significant potential for next-generation cancer immunotherapy. Extensive data from clinical trials (Fig. 2) and preclinical studies have shown that blocking HAVCR2 is a promising way to improve antitumor immunity.
Table 1 List of anti-HAVCR2 antibodies in clinical trials.1
Anti-HAVCR2 Monoclonal Antibodies at Creative Biolabs are characterized by high specificity and strict quality control.
Fig. 2 V3S-0522-YC2244 was analyzed in SDS-PAGE.
Fig. 3 V3S-0622-YC2647 detected HAVCR2 in ELISA.
Fig. 4 The purity of V3S-0622-YC2647 was analyzed by SEC-HPLC.
Anti-HAVCR2 Neutralizing Antibody (V3S-0622-YC2647) (CAT#: V3S-0622-YC2647)
Target: HAVCR2
Host Species: Human
Target Species: Human,
Application: ELISA,WB,FuncS,
Anti-HAVCR2 Neutralizing Antibody (V3S-0522-YC2244) (CAT#: V3S-0522-YC2244)
Target: HAVCR2
Host Species: Human
Target Species: Human,
Application: ELISA,WB,Block,FuncS,
Recombinant Anti-HAVCR2 Antibody (V3S-0522-YC2237) (CAT#: V3S-0522-YC2237)
Target: HAVCR2
Host Species: Mouse
Target Species: Human,
Application: FC,
Recombinant Anti-HAVCR2 Antibody (V3S-0522-YC2238) (CAT#: V3S-0522-YC2238)
Target: HAVCR2
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-HAVCR2 Neutralizing Antibody (V3S-0522-YC2239) (CAT#: V3S-0522-YC2239)
Target: HAVCR2
Host Species: Human
Target Species: Human,
Application: Block,FuncS,
Anti-HAVCR2 Neutralizing Antibody (V3S-0522-YC2240) (CAT#: V3S-0522-YC2240)
Target: HAVCR2
Host Species: Human
Target Species: Human,
Application: ELISA,FC,Block,
Anti-HAVCR2 (ECD domain) Neutralizing Antibody (V3S-0522-YC2241) (CAT#: V3S-0522-YC2241)
Target: HAVCR2
Host Species: Human
Target Species: Human,
Application: ELISA,Block,
Recombinant Anti-HAVCR2 Antibody (V3S-0522-YC2242) (CAT#: V3S-0522-YC2242)
Target: HAVCR2
Host Species: Mouse
Target Species: Human,
Application: ELISA,FuncS,
Recombinant Anti-HAVCR2 Antibody (V3S-0522-YC2243) (CAT#: V3S-0522-YC2243)
Target: HAVCR2
Host Species: Human
Target Species: Human,
Application: FuncS,
Recombinant Anti-HAVCR2 Antibody (V3S-0522-YC2245) (CAT#: V3S-0522-YC2245)
Target: HAVCR2
Host Species: Human
Target Species: Human,
Application: FuncS,
Recombinant Anti-HAVCR2 Antibody (V3S-0522-YC2246) (CAT#: V3S-0522-YC2246)
Target: HAVCR2
Host Species: Human
Target Species: Human, Cynomolgus,
Application: FC,ELISA,
Recombinant Anti-HAVCR2 Antibody (V3S-0522-YC2247) (CAT#: V3S-0522-YC2247)
Target: HAVCR2
Host Species: Human
Target Species: Human, Cynomolgus,
Application: FC,ELISA,
Recombinant Anti-HAVCR2 Antibody (V3S-0522-YC2248) (CAT#: V3S-0522-YC2248)
Target: HAVCR2
Host Species: Mouse
Target Species: Human, Cynomolgus,
Application: FC,ELISA,
Recombinant Anti-HAVCR2 Antibody (V3S-0522-YC6549) (CAT#: V3S-0522-YC6549)
Target: HAVCR2
Host Species: Mouse
Target Species: Human,
Application: ELISA,WB,FC,
Recombinant Anti-HAVCR2 Antibody (V3S-0522-YC6550) (CAT#: V3S-0522-YC6550)
Target: HAVCR2
Host Species: Mouse
Target Species: Human,
Application: ELISA,WB,FC,
Anti-Havcr2 Neutralizing Antibody (V3S-0822-YC1258) (CAT#: V3S-0822-YC1258)
Target: Havcr2
Host Species: Rat
Target Species: Mouse,
Application: Block,FC,
Anti-Havcr2 Neutralizing Antibody (V3S-0822-YC1259) (CAT#: V3S-0822-YC1259)
Target: Havcr2
Host Species: Rat
Target Species: Mouse,
Application: Block,FC,
Recombinant Anti-HAVCR2 Antibody (V3S-1022-YC334) (CAT#: V3S-1022-YC334)
Target: HAVCR2
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-HAVCR2 Antibody (V3S-1022-YC335) (CAT#: V3S-1022-YC335)
Target: HAVCR2
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-HAVCR2 Antibody (V3S-1022-YC336) (CAT#: V3S-1022-YC336)
Target: HAVCR2
Host Species: Mouse
Target Species: Human,
Application: FC,
Recombinant Anti-HAVCR2 Antibody (V3S-1022-YC3181) (CAT#: V3S-1022-YC3181)
Target: HAVCR2
Host Species: Mouse
Target Species: Human, Cynomolgus,
Application: ELISA,FC,
Recombinant Anti-HAVCR2 Antibody (V3S-1022-YC3182) (CAT#: V3S-1022-YC3182)
Target: HAVCR2
Host Species: Mouse
Target Species: Human, Cynomolgus,
Application: ELISA,FC,
Recombinant Anti-HAVCR2 Antibody (V3S-1022-YC3183) (CAT#: V3S-1022-YC3183)
Target: HAVCR2
Host Species: Mouse
Target Species: Human, Cynomolgus,
Application: ELISA,FC,
Recombinant Anti-HAVCR2 Antibody (V3S-1022-YC3184) (CAT#: V3S-1022-YC3184)
Target: HAVCR2
Host Species: Human
Target Species: Human, Cynomolgus,
Application: ELISA,FC,
Recombinant Anti-HAVCR2 Antibody (V3S-1022-YC3185) (CAT#: V3S-1022-YC3185)
Target: HAVCR2
Host Species: Human
Target Species: Human, Cynomolgus,
Application: ELISA,FC,
Recombinant Anti-HAVCR2 Antibody (V3S-1022-YC3186) (CAT#: V3S-1022-YC3186)
Target: HAVCR2
Host Species: Mouse
Target Species: Human, Cynomolgus,
Application: ELISA,FC,IHC,
Recombinant Anti-HAVCR2 Antibody (V3S-1022-YC3187) (CAT#: V3S-1022-YC3187)
Target: HAVCR2
Host Species: Human
Target Species: Human, Cynomolgus,
Application: ELISA,FC,IHC,
Recombinant Anti-HAVCR2 Antibody (V3S-1022-YC3188) (CAT#: V3S-1022-YC3188)
Target: HAVCR2
Host Species: Human
Target Species: Human, Cynomolgus,
Application: ELISA,FC,IHC,
Recombinant Anti-HAVCR2 Antibody (V3S-1222-YC520) (CAT#: V3S-1222-YC520)
Target: HAVCR2
Host Species: Mouse
Target Species: Human,
Application: WB,Inhib,ELISA,
Recombinant Anti-HAVCR2 Antibody (V3S-1222-YC521) (CAT#: V3S-1222-YC521)
Target: HAVCR2
Host Species: Mouse
Target Species: Human,
Application: WB,Inhib,ELISA,
Recombinant Anti-HAVCR2 Antibody (V3S-1222-YC522) (CAT#: V3S-1222-YC522)
Target: HAVCR2
Host Species: Mouse
Target Species: Human,
Application: WB,Inhib,ELISA,
Recombinant Anti-HAVCR2 Antibody (V3S-1222-YC523) (CAT#: V3S-1222-YC523)
Target: HAVCR2
Host Species: Mouse
Target Species: Human,
Application: WB,Inhib,ELISA,
Recombinant Anti-HAVCR2 Antibody (V3S-1222-YC524) (CAT#: V3S-1222-YC524)
Target: HAVCR2
Host Species: Mouse
Target Species: Human,
Application: WB,Inhib,ELISA,
Recombinant Anti-HAVCR2 Antibody (V3S-1222-YC525) (CAT#: V3S-1222-YC525)
Target: HAVCR2
Host Species: Mouse
Target Species: Human,
Application: WB,Inhib,ELISA,
Recombinant Anti-HAVCR2 Antibody (V3S-1222-YC693) (CAT#: V3S-1222-YC693)
Target: HAVCR2
Host Species: Mouse
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-HAVCR2 Antibody (V3S-1222-YC796) (CAT#: V3S-1222-YC796)
Target: HAVCR2
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-HAVCR2 Antibody (V3S-1222-YC797) (CAT#: V3S-1222-YC797)
Target: HAVCR2
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-HAVCR2 Antibody (V3S-1222-YC798) (CAT#: V3S-1222-YC798)
Target: HAVCR2
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-HAVCR2 Antibody (V3S-1222-YC799) (CAT#: V3S-1222-YC799)
Target: HAVCR2
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-HAVCR2 Antibody (V3S-1222-YC800) (CAT#: V3S-1222-YC800)
Target: HAVCR2
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-HAVCR2 Antibody (V3S-1222-YC801) (CAT#: V3S-1222-YC801)
Target: HAVCR2
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-HAVCR2 Antibody (V3S-1222-YC802) (CAT#: V3S-1222-YC802)
Target: HAVCR2
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-HAVCR2 Antibody (V3S-1222-YC803) (CAT#: V3S-1222-YC803)
Target: HAVCR2
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-HAVCR2 Antibody (V3S-1222-YC804) (CAT#: V3S-1222-YC804)
Target: HAVCR2
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-HAVCR2 Antibody (V3S-1222-YC805) (CAT#: V3S-1222-YC805)
Target: HAVCR2
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-HAVCR2 Antibody (V3S-1222-YC806) (CAT#: V3S-1222-YC806)
Target: HAVCR2
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-HAVCR2 Antibody (V3S-1222-YC807) (CAT#: V3S-1222-YC807)
Target: HAVCR2
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-HAVCR2 Antibody (V3S-1222-YC808) (CAT#: V3S-1222-YC808)
Target: HAVCR2
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-HAVCR2 Antibody (V3S-1222-YC809) (CAT#: V3S-1222-YC809)
Target: HAVCR2
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-HAVCR2 Antibody (V3S-1222-YC810) (CAT#: V3S-1222-YC810)
Target: HAVCR2
Host Species: Human
Target Species: Human,
Application: ELISA,
