Interleukin 23 Subunit Alpha (IL23A), also known as SGRF or P19, is a crucial factor mediating IL23 signal transduction. IL-23 is a critical regulator of immune cell activation and cytokine production. IL23R, as a subunit of the IL23 receptor, is located on chromosome 1 and is a key hub for the function of IL23. Furthermore, IL23R belongs to the type I cytokine receptor family. The IL23 R extracellular domain contains seven potential N-linked glycosylation sites, and the transmembrane domain contains sequences similar to the characteristics of cytokine receptors. Targeting IL-23 signaling with the aid of specific neutralizing antibodies shows great promise in many inflammatory diseases.
Its Gene ID: 51561, UniProtKB ID: Q9NPF7, and OMIM ID: 605580.
Fig.1 IL23 controls the activation of immune cells.1
IL-23A is a promoter of tumor occurrence and growth. Overexpression of IL23A mRNA is closely associated with various human cancers, such as colon cancer, melanoma, breast cancer, and lung cancer. Furthermore, IL23A deficiency is beneficial in resistance to chemically induced tumors.
IL-23A overexpression is directly linked to inflammation in multiple organs. Therefore, IL23 upregulation is considered to be a key trigger of many inflammatory and autoimmune diseases. It is worth noting that IL23R has exhibited significant association with other diseases, such as ankylosing spondylitis and psoriasis.
IL-23/IL-17 axis plays an important regulatory role in various inflammatory diseases. In addition, the discovery of the IL-23/IL-17 pathway provides new insights into the underlying mechanisms of inflammatory diseases. Currently, therapies targeting the IL-23/IL-17 signaling pathway are gradually emerging as therapeutic options for inflammatory diseases.
Fig.2 Signaling pathway of IL23A.2
Creative Biolabs offers a variety of proven specific neutralizing antibodies to provide a powerful boost for your projects. Our diverse antibodies targeting IL23A can serve different experiments, including but not limited to immunofluorescence, western blotting, and immunohistochemistry. Please don't hesitate to contact us for more IL23A antibody details.
Anti-IL23A Neutralizing Antibody (V3S-0622-YC4706) (CAT#: V3S-0622-YC4706)
Target: IL23A
Host Species: Human
Target Species: Human,
Application: WB,DB,Neut,ELISA,IF,IP,FuncS,FC,ICC,
Recombinant Anti-IL23A Antibody (V3S-0622-YC4707) (CAT#: V3S-0622-YC4707)
Target: IL23A
Host Species: Human
Target Species: Human,
Application: WB,DB,ELISA,
Recombinant Anti-IL23A Antibody (V3S-0622-YC3539) (CAT#: V3S-0622-YC3539)
Target: IL23A
Host Species: Mouse
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL23A Antibody (V3S-0622-YC3540) (CAT#: V3S-0622-YC3540)
Target: IL23A
Host Species: Mouse
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL23A Antibody (V3S-0622-YC3541) (CAT#: V3S-0622-YC3541)
Target: IL23A
Host Species: Mouse
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL23A Antibody (V3S-0622-YC3542) (CAT#: V3S-0622-YC3542)
Target: IL23A
Host Species: Mouse
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL23A Antibody (V3S-0622-YC3543) (CAT#: V3S-0622-YC3543)
Target: IL23A
Host Species: Mouse
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL23A Antibody (V3S-0622-YC3544) (CAT#: V3S-0622-YC3544)
Target: IL23A
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL23A Antibody (V3S-0622-YC3545) (CAT#: V3S-0622-YC3545)
Target: IL23A
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL23A Antibody (V3S-0622-YC3546) (CAT#: V3S-0622-YC3546)
Target: IL23A
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL23A Antibody (V3S-0622-YC4690) (CAT#: V3S-0622-YC4690)
Target: IL23A
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL23A Antibody (V3S-0622-YC4691) (CAT#: V3S-0622-YC4691)
Target: IL23A
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL23A Antibody (V3S-0622-YC4692) (CAT#: V3S-0622-YC4692)
Target: IL23A
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL23A Antibody (V3S-0622-YC4693) (CAT#: V3S-0622-YC4693)
Target: IL23A
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL23A Antibody (V3S-0622-YC4694) (CAT#: V3S-0622-YC4694)
Target: IL23A
Host Species: Mouse
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-IL23A Antibody (V3S-0622-YC4695) (CAT#: V3S-0622-YC4695)
Target: IL23A
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL23A Antibody (V3S-0622-YC4696) (CAT#: V3S-0622-YC4696)
Target: IL23A
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL23A Antibody (V3S-0622-YC4697) (CAT#: V3S-0622-YC4697)
Target: IL23A
Host Species: Mouse
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-IL23A Antibody (V3S-0622-YC4698) (CAT#: V3S-0622-YC4698)
Target: IL23A
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-IL23A Antibody (V3S-0622-YC4699) (CAT#: V3S-0622-YC4699)
Target: IL23A
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-IL23A Antibody (V3S-0622-YC4700) (CAT#: V3S-0622-YC4700)
Target: IL23A
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-IL23A Antibody (V3S-0622-YC4701) (CAT#: V3S-0622-YC4701)
Target: IL23A
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Rat Anti-IL23A Antibody (V3S-0622-YC4703) (CAT#: V3S-0622-YC4703)
Target: IL23A
Host Species: Rat
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL23A Antibody (V3S-0622-YC4704) (CAT#: V3S-0622-YC4704)
Target: IL23A
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL23A Antibody (V3S-0622-YC4705) (CAT#: V3S-0622-YC4705)
Target: IL23A
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL23A Antibody (V3S-0522-YC2397) (CAT#: V3S-0522-YC2397)
Target: IL23A
Host Species: Mouse
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL23A Antibody (V3S-0522-YC2398) (CAT#: V3S-0522-YC2398)
Target: IL23A
Host Species: Mouse
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL23A Antibody (V3S-0522-YC2399) (CAT#: V3S-0522-YC2399)
Target: IL23A
Host Species: Mouse
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL23A Antibody (V3S-0522-YC2400) (CAT#: V3S-0522-YC2400)
Target: IL23A
Host Species: Human
Target Species: Human, Cynomolgus,
Application: ELISA,FuncS,
Recombinant Anti-IL23A Antibody (V3S-0522-YC2401) (CAT#: V3S-0522-YC2401)
Target: IL23A
Host Species: Human
Target Species: Human, Cynomolgus,
Application: ELISA,FuncS,
Recombinant Anti-IL23A Antibody (V3S-0522-YC2402) (CAT#: V3S-0522-YC2402)
Target: IL23A
Host Species: Human
Target Species: Human, Cynomolgus,
Application: ELISA,FuncS,
Anti-IL23A Neutralizing Antibody (V3S-0522-YC7988) (CAT#: V3S-0522-YC7988)
Target: IL23A
Host Species: Human
Target Species: Human,
Application: Neut,
Rabbit Anti-IL23A Neutralizing Antibody (V3S-0822-YC1701) (CAT#: V3S-0822-YC1701)
Target: IL23A
Host Species: Rabbit
Target Species: Human,
Application: Neut,WB,
Anti-IL23A Neutralizing Antibody (V3S-0822-YC1702) (CAT#: V3S-0822-YC1702)
Target: IL23A
Host Species: Human
Target Species: Human,
Application: Neut,
Anti-Il23a (C-terminus) Neutralizing Antibody (V3S-0822-YC1704) (CAT#: V3S-0822-YC1704)
Target: Il23a
Host Species: Mouse
Target Species: Mouse,
Application: Neut,
Anti-Il23a Neutralizing Antibody (V3S-0822-YC2741) (CAT#: V3S-0822-YC2741)
Target: Il23a
Host Species: Rat
Target Species: Mouse,
Application: Neut,WB,
Recombinant Anti-IL23A Antibody (V3S-1022-YC707) (CAT#: V3S-1022-YC707)
Target: IL23A
Host Species: Mouse
Target Species: Human,
Application: Inhib,
Recombinant Anti-IL23A Antibody (V3S-1022-YC710) (CAT#: V3S-1022-YC710)
Target: IL23A
Host Species: Mouse
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL23A Antibody (V3S-1022-YC716) (CAT#: V3S-1022-YC716)
Target: IL23A
Host Species: Mouse
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL23A Antibody (V3S-1022-YC1030) (CAT#: V3S-1022-YC1030)
Target: IL23A
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL23A Antibody (V3S-1022-YC1031) (CAT#: V3S-1022-YC1031)
Target: IL23A
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL23A Antibody (V3S-1022-YC1032) (CAT#: V3S-1022-YC1032)
Target: IL23A
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL23A Antibody (V3S-1022-YC1033) (CAT#: V3S-1022-YC1033)
Target: IL23A
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL23A Antibody (V3S-1022-YC1034) (CAT#: V3S-1022-YC1034)
Target: IL23A
Host Species: Mouse
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL23A Antibody (V3S-1022-YC1035) (CAT#: V3S-1022-YC1035)
Target: IL23A
Host Species: Mouse
Target Species: Human,
Application: ELISA,
Recombinant Anti-IL23A Antibody (V3S-1022-YC1320) (CAT#: V3S-1022-YC1320)
Target: IL23A
Host Species: Mouse
Target Species: Human,
Application: ELISA,
Anti-IL23A (aa 81-140) Neutralizing Antibody (V3S-1022-YC3191) (CAT#: V3S-1022-YC3191)
Target: IL23A
Host Species: Human
Target Species: Human, Cynomolgus, Rabbit,
Application: ELISA,FC,Neut,
Anti-IL23A (aa 193-205) Neutralizing Antibody (V3S-1022-YC3196) (CAT#: V3S-1022-YC3196)
Target: IL23A
Host Species: Human
Target Species: Human,
Application: ELISA,FC,Block,
Recombinant Anti-IL23A Antibody (V3S-1222-YC241) (CAT#: V3S-1222-YC241)
Target: IL23A
Host Species: Human
Target Species: Human,
Application: Inhib,ELISA,
Recombinant Anti-IL23A Antibody (V3S-1222-YC242) (CAT#: V3S-1222-YC242)
Target: IL23A
Host Species: Human
Target Species: Human,
Application: Inhib,ELISA,
