LH Specific Neutra™ Antibody Products

Are your drug development efforts hindered by prolonged timelines or challenges in developing neutralizing antibodies against complex glycoprotein targets? Creative Biolabs' anti-LH neutra™ antibodies leverage advanced recombinant antibody engineering to deliver high-specificity tools that facilitate preclinical validation, therapeutic development, and diagnostic assay design for reproductive and endocrine disorders.

Introduction to LH

Luteinizing hormone (LH), a glycoprotein secreted by the anterior pituitary gland, plays a central role in reproductive physiology. It regulates ovulation in females by triggering follicular maturation and corpus luteum formation, while in males, it stimulates testosterone synthesis via Leydig cell activation. Circulating LH levels are tightly controlled by hypothalamic-pituitary-gonadal (HPG) axis feedback mechanisms, making it a critical biomarker for assessing fertility, puberty onset, and endocrine disorders.

• Structural Insights

LH is a heterodimer composed of two non-covalently linked subunits: a common α-subunit (shared with FSH, TSH, and hCG) and a unique β-subunit that confers receptor specificity. The β-subunit contains three leucine-rich repeats and two disulfide-bonded loops critical for binding to the LH receptor (LHR), a G protein-coupled receptor (GPCR). Post-translational glycosylation at specific asparagine residues enhances hormone stability and bioactivity, while mutations in these regions impair receptor activation.

• Related Signaling Pathways

LH binding stimulates LHR, resulting in cAMP/PKA and β-arrestin-mediated pathways. These cascades stimulate steroidogenesis, gene transcription, and cellular proliferation. Dysregulation of these pathways contributes to pathologies such as polycystic ovary syndrome (PCOS) and hypogonadism. Additionally, elevated LH signaling in postmenopausal women is linked to hormone-sensitive cancers, highlighting its therapeutic relevance.

• Disease Associations

Abnormal LH levels or receptor function underpin numerous illnesses:

-Infertility: Low LH disrupts ovulation and spermatogenesis, while elevated LH in PCOS exacerbates hyperandrogenism.

-Hypogonadism: Congenital or acquired LHR defects impair steroidogenesis.

-Oncology: Overexpression of LH or LHR in ovarian, breast, and prostate cancers correlates with tumor progression and resistance to hormone therapies.

Fig. 1 Effects of LH on spermatogenesis, Leydig cells (LCs), and sperm cells.¹

Applications of Anti-LH Neutralizing Antibodies

• Enhancing Assisted Reproductive Technologies (ART)

Anti-LH antibodies enable precise monitoring of LH surges during ovarian stimulation, reducing cycle variability in IVF protocols. Neutralizing antibodies also aid in developing LH-suppressive therapies for conditions like PCOS, where excessive LH drives hyperandrogenism.

• Treating Hormone-Dependent Disorders

In hypogonadotropic hypogonadism, anti-LH antibodies serve as reference tools for calibrating hormone replacement therapies. Conversely, neutralizing LH in precocious puberty models demonstrates potential for delaying premature HPG axis activation.

• Oncology Research and Therapy

LH receptor blockade via neutralizing antibodies suppresses tumor growth in preclinical models of ovarian cancer. These antibodies also improve sensitivity to aromatase inhibitors in estrogen receptor-positive breast cancer by attenuating LH-driven estrogen synthesis.

• Diagnostic Assay Development

Our antibodies underpin high-precision LH immunoassays critical for diagnosing infertility, menopause, and pituitary dysfunction. Their low cross-reactivity ensures accurate differentiation between LH and homologous hormones in multiplex panels.

Our Anti-LH Neutralizing Antibody Products

Creative Biolabs' anti-LH antibodies are rigorously validated for specificity, sensitivity, and functional efficacy. These antibodies target conformational epitopes within the LH β-subunit, effectively blocking LHR binding without cross-reacting with FSH or hCG. Key features include:

-High Affinity: Engineered paratopes achieve sub-nanomolar binding to both free and receptor-bound LH.

-Functional Neutralization: Inhibit LH-induced cAMP production in vitro (IC₅₀ < 1 nM).

-Versatility: Optimized for ELISA (detection limit: 0.1 ng/mL), immunohistochemistry, and biosensor-based assays. Applications span therapeutic antibody development, LH quantification in fertility diagnostics, and mechanistic studies of HPG axis dysregulation.

Creative Biolabs offers rigorously validated anti-LH neutra™ antibodies to empower your research and therapeutic development. With unmatched specificity and robust performance across assays, our products accelerate research breakthroughs in reproductive health, oncology, and endocrine disorders. Contact our team to discuss customized solutions for your LH-targeted projects.

REFERENCE

1. Lei, Tian, Yu Yang, and Wan-Xi Yang. "Luteinizing hormone regulates testosterone production, leydig cell proliferation, differentiation, and circadian rhythm during spermatogenesis." International Journal of Molecular Sciences 26.8 (2025): 3548. Distributed under Open Access license CC BY 4.0, without modification. https://doi.org/10.3390/ijms26083548