NRP1 Specific Neutra™ Antibody Products

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Neuropilin 1 (NRP1), also known as VEGF165R or CD304, is an essential member of the neuropilin family. NRP1 is a critical membrane-bound coreceptor. NRP1 contains a specific intracellular domain, a short transmembrane domain, and a large extracellular domain. This special structure allows NRP1 to participate in multiple signal transduction pathways. NRP1 binds various ligands, which provides the opportunity for it to participate in the regulation of cell survival and migration.

Its Gene ID: 8829, UniProtKB ID: O14786, and OMIM ID: 602069.

Fig.1 Structure of neuropilin. Fig.1 Schematic presentation of neuropilin’s structure.¹

Function

As a transmembrane glycoprotein, NRP1 serves as a receptor for many extracellular ligands, including vascular endothelial growth factors (for example, VEGFA), class III/IV signaling proteins, and transforming growth factor β. NRP1 has been shown to be closely connected to a variety of life activities, including cell survival, cell migration, axon guidance, and angiogenesis. Furthermore, NRP1 also plays an essential role in regulating tumor angiogenesis, tumor proliferation, and migration.

NRP1 Signaling Pathways

It has been reported that NRP1 activates the NF-κB pathway to participate in the regulation of keratinocyte proliferation. In addition, the VEGF/NRP1 signaling pathway formed by VEGF and NRP1 is a crucial regulator of angiogenesis.

Fig.2 Simplified diagram of the neuropilin-1 signaling. Fig.2 Schematic presentation of the neuropilin-1 signaling complexes.¹

NRP1 and Diseases

Increasing evidence reveals that NRP1 may be related to vascularization in cancer. Additionally, abnormalities in NRP1 have been associated with the progression of several cancers, including prostate, colon, brain, breast, and lung cancers. NRP1 levels were also positively relevant to metastasis in non-small cell lung cancer. NRP1 is also closely associated with SARS-CoV-2 infection in humans. The spike protein of specific influenza viruses can bind to specific sites on NRP1 on the cell surface, thereby initiating virus entry into host cells.

Therapeutics Targeting NRP1

Increasing evidence indicates that NRP1 is a valuable therapeutic target for anti-angiogenic therapy. Antagonists targeting NRP1 have been shown to have promising effects. At present, a variety of blocking monoclonal antibodies targeting the extracellular domain of NRP1 have been developed, aiming to specifically block NRP1 receptor function.

NRP1 Antibodies

As an expert in NRP1 antibody research, Creative Biolabs is committed to providing diverse NRP1 antibodies for research use only to customers in more than 30 countries and regions around the world. Our highly specific antibody products target NRP1 in mouse, rat as well as human samples. Our NRP1 antibodies can be used in a variety of scientific applications, including immunohistochemistry, flow cytometry, western blot, and ELISA. You can choose an antibody that matches your research goals from dozens of NRP1 antibody products. Please contact us for further details on NRP1 antibodies.

REFERENCES

Bondeva, Tzvetanka, and Gunter Wolf. "Role of neuropilin-1 in diabetic nephropathy." Journal of clinical medicine 4.6 (2015): 1293-1311. Distributed under Open Access license CC BY 4.0, without modification.

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