Reticulocyte-binding protein homolog 5

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The leading vaccine candidates for a P. falciparum blood-stage malaria vaccine are members of a heterotrimeric complex containing reticulocyte-binding protein homolog 5 (RH5), cysteinerich protective antigen (CyRPA), and RH5-interacting protein (RIPR), collectively called the "RCR complex"15. Each member of this complex is highly conserved, essential for erythrocyte invasion, and capable of inducing cross-strain neutralizing antibodies. Of the RCR components, vaccine development is most advanced for RH5. This is the first member of the complex to enter clinical vaccine trials. RH5 has been shown to protect non-human primates from developing malaria in a heterologous challenge model19 and, in a human challenge study, successfully reduced the parasite multiplication rate and delayed time to the onset of symptoms.

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Anti-PfRH5 Neutralizing Antibody (V3S-0522-YC7536) (CAT#: V3S-0522-YC7536)

Target: PfRH5

Host Species: Mouse

Target Species: Plasmodium falciparum,

Application: WB,Block,FuncS,