Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules. Diseases associated with SULF2 include Achondrogenesis, Type Ib and Atelosteogenesis. Gene Ontology (GO) annotations related to this gene include calcium ion binding and arylsulfatase activity.