TNF Receptor Superfamily Member 9 (TNFRSF9), also known as CD137 and 4-1BB, is a single-pass type I membrane protein. TNFRSF9 is overexpressed in normal tissues such as the spleen and whole blood. As a member of the TNF receptor superfamily, TNFRSF9 is the receptor for TNFSF9/4-1BBL and contributes to T cell proliferation, development, and survival.
Its Gene ID is 3604, OMIM ID is 602250, and UniProtKB ID is Q07011.
In the regulation of the immune system, the co-stimulator TNFRSF9 is involved in some important functions:
TNFRSF9 is the most robust target among TNFRSF co-stimulatory receptors, and a promising target for anti-tumor drug development. Advanced technologies such as TNFRSF9-based agonistic monoclonal antibodies, bispecific antibodies, and anti-TNFRSF9 antibodies with an additional safety switch are currently investigated for types of tumors.
Fig.1 The immuno-oncology strategy of TNFRSF9 based monoclonal and bispecific antibodies.1
Mono- and combination immunotherapy with the anti-TNFRSF9 antibodies has already led to promising clinical results in B-cell malignancies and solid tumors.1 The challenge of reducing hepatotoxicity and maintaining the agonistic efficacy of TNFRSF9 may addressed by the TNFRSF9-based bispecific compounds listed below.
Tab.1 TNFRSF9 targeting bispecific molecules in clinical trials.1
Creative Biolabs offers a comprehensive range of more than eighty anti-TNFRSF9 antibodies. These high-quality antibodies are involved in six research areas with fourteen applications. If you are interested in recombinant or customized anti-TNFRSF9 antibodies, please feel free to contact us.
Reference
Anti-TNFRSF9 (ECD domain) Neutralizing Antibody (V3S-0622-YC5675) (CAT#: V3S-0622-YC5675)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: WB,ELISA,FC,IP,FuncS,IF,Neut,ICC,
Recombinant Anti-TNFRSF9 Antibody (V3S-0522-YC1483) (CAT#: V3S-0522-YC1483)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: WB,ELISA,IHC,FC,IP,IF,FuncS,
Anti-TNFRSF9 (ECD domain) Neutralizing Antibody (V3S-0622-YC2704) (CAT#: V3S-0622-YC2704)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-0522-YC1969) (CAT#: V3S-0522-YC1969)
Target: TNFRSF9
Host Species: Mouse
Target Species: Human, Monkey,
Application: FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-0522-YC1970) (CAT#: V3S-0522-YC1970)
Target: TNFRSF9
Host Species: Human
Target Species: Human, Monkey,
Application: FuncS,
Anti-Tnfrsf9 (aa 24-187) Neutralizing Antibody (V3S-0822-YC2531) (CAT#: V3S-0822-YC2531)
Target: Tnfrsf9
Host Species: Mouse
Target Species: Mouse,
Application: Block,WB,
Hamster Anti-Tnfrsf9 Neutralizing Antibody (V3S-0822-YC2532) (CAT#: V3S-0822-YC2532)
Target: Tnfrsf9
Host Species: Hamster
Target Species: Mouse,
Application: FC,Block,
Anti-Tnfrsf9 Neutralizing Antibody (V3S-0822-YC2533) (CAT#: V3S-0822-YC2533)
Target: Tnfrsf9
Host Species: Rat
Target Species: Mouse,
Application: Neut,WB,
Recombinant Anti-TNFRSF9 Antibody (V3S-1022-YC2526) (CAT#: V3S-1022-YC2526)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-TNFRSF9 Antibody (V3S-1022-YC2527) (CAT#: V3S-1022-YC2527)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Anti-TNFRSF9 Neutralizing Antibody (V3S-1022-YC2531) (CAT#: V3S-1022-YC2531)
Target: TNFRSF9
Host Species: Human
Target Species: Human, Cynomolgus,
Application: Block,ELISA,FC,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC634) (CAT#: V3S-1222-YC634)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC635) (CAT#: V3S-1222-YC635)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC636) (CAT#: V3S-1222-YC636)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC637) (CAT#: V3S-1222-YC637)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC638) (CAT#: V3S-1222-YC638)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC639) (CAT#: V3S-1222-YC639)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC640) (CAT#: V3S-1222-YC640)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC641) (CAT#: V3S-1222-YC641)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC642) (CAT#: V3S-1222-YC642)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC643) (CAT#: V3S-1222-YC643)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC644) (CAT#: V3S-1222-YC644)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC645) (CAT#: V3S-1222-YC645)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC646) (CAT#: V3S-1222-YC646)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC647) (CAT#: V3S-1222-YC647)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC648) (CAT#: V3S-1222-YC648)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC649) (CAT#: V3S-1222-YC649)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC650) (CAT#: V3S-1222-YC650)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC651) (CAT#: V3S-1222-YC651)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC652) (CAT#: V3S-1222-YC652)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC653) (CAT#: V3S-1222-YC653)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC654) (CAT#: V3S-1222-YC654)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC655) (CAT#: V3S-1222-YC655)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC656) (CAT#: V3S-1222-YC656)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC657) (CAT#: V3S-1222-YC657)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC658) (CAT#: V3S-1222-YC658)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC659) (CAT#: V3S-1222-YC659)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC660) (CAT#: V3S-1222-YC660)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC661) (CAT#: V3S-1222-YC661)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC662) (CAT#: V3S-1222-YC662)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC663) (CAT#: V3S-1222-YC663)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC664) (CAT#: V3S-1222-YC664)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC665) (CAT#: V3S-1222-YC665)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC666) (CAT#: V3S-1222-YC666)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC667) (CAT#: V3S-1222-YC667)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC668) (CAT#: V3S-1222-YC668)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC669) (CAT#: V3S-1222-YC669)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC670) (CAT#: V3S-1222-YC670)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC671) (CAT#: V3S-1222-YC671)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC672) (CAT#: V3S-1222-YC672)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
