TNF Receptor Superfamily Member 9 (TNFRSF9), also known as CD137 and 4-1BB, is a single-pass type I membrane protein. TNFRSF9 is overexpressed in normal tissues such as the spleen and whole blood. As a member of the TNF receptor superfamily, TNFRSF9 is the receptor for TNFSF9/4-1BBL and contributes to T cell proliferation, development, and survival.
Its Gene ID is 3604, OMIM ID is 602250, and UniProtKB ID is Q07011.
In the regulation of the immune system, the co-stimulator TNFRSF9 is involved in some important functions:
TNFRSF9 is the most robust target among TNFRSF co-stimulatory receptors, and a promising target for anti-tumor drug development. Advanced technologies such as TNFRSF9-based agonistic monoclonal antibodies, bispecific antibodies, and anti-TNFRSF9 antibodies with an additional safety switch are currently investigated for types of tumors.
Fig.1 The immuno-oncology strategy of TNFRSF9 based monoclonal and bispecific antibodies.1
Mono- and combination immunotherapy with the anti-TNFRSF9 antibodies has already led to promising clinical results in B-cell malignancies and solid tumors.1 The challenge of reducing hepatotoxicity and maintaining the agonistic efficacy of TNFRSF9 may addressed by the TNFRSF9-based bispecific compounds listed below.
Tab.1 TNFRSF9 targeting bispecific molecules in clinical trials.1
Creative Biolabs offers a comprehensive range of more than eighty anti-TNFRSF9 antibodies. These high-quality antibodies are involved in six research areas with fourteen applications. If you are interested in recombinant or customized anti-TNFRSF9 antibodies, please feel free to contact us.
Reference
Recombinant Anti-TNFRSF9 Antibody (V3S-0622-YC536) (CAT#: V3S-0622-YC536)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-TNFRSF9 Antibody (V3S-0622-YC537) (CAT#: V3S-0622-YC537)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-TNFRSF9 (ECD domain) Antibody (V3S-0622-YC538) (CAT#: V3S-0622-YC538)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: Costim,FC,
Anti-TNFRSF9 Neutralizing Antibody (V3S-0622-YC2701) (CAT#: V3S-0622-YC2701)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFRSF9 Neutralizing Antibody (V3S-0622-YC2702) (CAT#: V3S-0622-YC2702)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFRSF9 Neutralizing Antibody (V3S-0622-YC2703) (CAT#: V3S-0622-YC2703)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFRSF9 (ECD domain) Neutralizing Antibody (V3S-0622-YC2704) (CAT#: V3S-0622-YC2704)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFRSF9 (ECD domain) Neutralizing Antibody (V3S-0622-YC5675) (CAT#: V3S-0622-YC5675)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: WB,ELISA,FC,IP,FuncS,IF,Neut,ICC,
Recombinant Anti-TNFRSF9 Antibody (V3S-0522-YC1483) (CAT#: V3S-0522-YC1483)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: WB,ELISA,IHC,FC,IP,IF,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-0522-YC1965) (CAT#: V3S-0522-YC1965)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: Agonist,
Recombinant Anti-TNFRSF9 Antibody (V3S-0522-YC1966) (CAT#: V3S-0522-YC1966)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,
Anti-TNFRSF9 Neutralizing Antibody (V3S-0522-YC1967) (CAT#: V3S-0522-YC1967)
Target: TNFRSF9
Host Species: Human
Target Species: Human, Cynomolgus,
Application: ELISA,FC,Block,
Anti-TNFRSF9 Neutralizing Antibody (V3S-0522-YC1968) (CAT#: V3S-0522-YC1968)
Target: TNFRSF9
Host Species: Human
Target Species: Human, Cynomolgus,
Application: ELISA,FC,Block,
Recombinant Anti-TNFRSF9 Antibody (V3S-0522-YC1969) (CAT#: V3S-0522-YC1969)
Target: TNFRSF9
Host Species: Mouse
Target Species: Human, Monkey,
Application: FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-0522-YC1970) (CAT#: V3S-0522-YC1970)
Target: TNFRSF9
Host Species: Human
Target Species: Human, Monkey,
Application: FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1022-YC33) (CAT#: V3S-1022-YC33)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: ELISA,
Recombinant Anti-TNFRSF9 Antibody (V3S-1022-YC1791) (CAT#: V3S-1022-YC1791)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-TNFRSF9 Antibody (V3S-1022-YC2526) (CAT#: V3S-1022-YC2526)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-TNFRSF9 Antibody (V3S-1022-YC2527) (CAT#: V3S-1022-YC2527)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-TNFRSF9 Antibody (V3S-1022-YC2528) (CAT#: V3S-1022-YC2528)
Target: TNFRSF9
Host Species: Human
Target Species: Human, Cynomolgus,
Application: ELISA,FC,
Recombinant Anti-TNFRSF9 Antibody (V3S-1022-YC2529) (CAT#: V3S-1022-YC2529)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,
Recombinant Anti-TNFRSF9 Antibody (V3S-1022-YC2530) (CAT#: V3S-1022-YC2530)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,
Anti-TNFRSF9 (ECD domain) Neutralizing Antibody (V3S-1022-YC2531) (CAT#: V3S-1022-YC2531)
Target: TNFRSF9
Host Species: Human
Target Species: Human, Cynomolgus,
Application: Block,ELISA,FC,
Anti-TNFRSF9 (ECD domain) Neutralizing Antibody (V3S-1022-YC2532) (CAT#: V3S-1022-YC2532)
Target: TNFRSF9
Host Species: Human
Target Species: Human, Cynomolgus,
Application: Block,ELISA,FC,
Recombinant Anti-TNFRSF9 Antibody (V3S-1022-YC2533) (CAT#: V3S-1022-YC2533)
Target: TNFRSF9
Host Species: Human
Target Species: Human, Cynomolgus,
Application: ELISA,FC,
Recombinant Anti-TNFRSF9 Antibody (V3S-1022-YC2534) (CAT#: V3S-1022-YC2534)
Target: TNFRSF9
Host Species: Human
Target Species: Human, Cynomolgus,
Application: ELISA,FC,
Recombinant Anti-TNFRSF9 Antibody (V3S-1022-YC2535) (CAT#: V3S-1022-YC2535)
Target: TNFRSF9
Host Species: Mouse
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC634) (CAT#: V3S-1222-YC634)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC635) (CAT#: V3S-1222-YC635)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC636) (CAT#: V3S-1222-YC636)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC637) (CAT#: V3S-1222-YC637)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC638) (CAT#: V3S-1222-YC638)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC639) (CAT#: V3S-1222-YC639)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC640) (CAT#: V3S-1222-YC640)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC641) (CAT#: V3S-1222-YC641)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC642) (CAT#: V3S-1222-YC642)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC643) (CAT#: V3S-1222-YC643)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC644) (CAT#: V3S-1222-YC644)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC645) (CAT#: V3S-1222-YC645)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC646) (CAT#: V3S-1222-YC646)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC647) (CAT#: V3S-1222-YC647)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC648) (CAT#: V3S-1222-YC648)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC649) (CAT#: V3S-1222-YC649)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC650) (CAT#: V3S-1222-YC650)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Recombinant Anti-TNFRSF9 Antibody (V3S-1222-YC651) (CAT#: V3S-1222-YC651)
Target: TNFRSF9
Host Species: Human
Target Species: Human,
Application: FC,FuncS,
Anti-Tnfrsf9 (aa 24-187) Neutralizing Antibody (V3S-0822-YC2531) (CAT#: V3S-0822-YC2531)
Target: Tnfrsf9
Host Species: Mouse
Target Species: Mouse,
Application: Block,WB,
Anti-Tnfrsf9 Neutralizing Antibody (V3S-0822-YC2532) (CAT#: V3S-0822-YC2532)
Target: Tnfrsf9
Host Species: Hamster
Target Species: Mouse,
Application: FC,Block,
Anti-Tnfrsf9 Neutralizing Antibody (V3S-0822-YC2533) (CAT#: V3S-0822-YC2533)
Target: Tnfrsf9
Host Species: Rat
Target Species: Mouse,
Application: Neut,WB,
Recombinant Anti-Tnfrsf9 Antibody (V3S-0822-YC2650) (CAT#: V3S-0822-YC2650)
Target: Tnfrsf9
Host Species: Rat
Target Species: Mouse,
Application: Activ,
Recombinant Anti-Tnfrsf9 Antibody (V3S-0822-YC2651) (CAT#: V3S-0822-YC2651)
Target: Tnfrsf9
Host Species: Rat
Target Species: Mouse,
Application: Stim,
