TNFSF13B (TNF Superfamily Member 13b), also known as BAFF (B-cell Activating Factor) or CD257, is a cytokine that plays a vital role in the immune system. Creative Biolabs provides comprehensive and in-depth information about TNFSF13B to help clients better understand the characteristics and potential applications of this key target.
TNFSF13B, widely expressed in various cell types such as monocytes, dendritic cells, and bone marrow stromal cells, plays a core role in the survival, proliferation, and differentiation of B cells. It also activates T cells, promoting their proliferation and differentiation, thus demonstrating multiple influences in immune regulation. TNFSF13B engages with three principal receptors — B-cell Activating Factor Receptor (BAFF-R), Transmembrane Activator and Calcium Modulator-Cyclophilin Ligand Interactor (TACI), and B-cell Maturation Antigen (BCMA) — initiating critical signaling cascades such as NF-κB, PI3K/Akt, and MAPK. These pathways play a pivotal role in diverse cellular processes and immunological functions.
Fig.1 Expression of BAFFR, TACI and BCMA in B cell development.1
The dysregulation of TNFSF13B expression is intricately linked to the development of a variety of human autoimmune disorders.
These findings reveal the significant role of TNFSF13B in the development of autoimmune diseases, especially in promoting the survival and function of pathological B cells.
In clinical medicine, TNFSF13B has been proven to be a potential therapeutic target, and antibody drugs targeting it have been used to treat autoimmune diseases such as SLE and rheumatoid arthritis.
In the future medical field, we have reason to believe that more precise anti-TNFSF13B antibody drugs will become a new direction in research targeting TNFSF13B. This is because antibody drugs targeting TNFSF13B not only offer more effective treatment options but also significantly reduce potential side effects. To support the development of this research field, Creative Biolabs provides a complete set of high-quality antibody products and customized services targeting TNFSF13B, aimed at assisting and accelerating the research progress of scientists in this field. For more information about our products or to discuss your specific requirements, don't hesitate to contact us.
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC5689) (CAT#: V3S-0622-YC5689)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: FuncS,IF,Neut,ELISA,FC,IP,IHC,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2705) (CAT#: V3S-0622-YC2705)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: FC,IP,ELISA,Neut,FuncS,IF,ICC,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2706) (CAT#: V3S-0622-YC2706)
Target: TNFSF13B
Host Species: Mouse
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2707) (CAT#: V3S-0622-YC2707)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2708) (CAT#: V3S-0622-YC2708)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2709) (CAT#: V3S-0622-YC2709)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2710) (CAT#: V3S-0622-YC2710)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2711) (CAT#: V3S-0622-YC2711)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2712) (CAT#: V3S-0622-YC2712)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2713) (CAT#: V3S-0622-YC2713)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2714) (CAT#: V3S-0622-YC2714)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2715) (CAT#: V3S-0622-YC2715)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2716) (CAT#: V3S-0622-YC2716)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2717) (CAT#: V3S-0622-YC2717)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2718) (CAT#: V3S-0622-YC2718)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2719) (CAT#: V3S-0622-YC2719)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2720) (CAT#: V3S-0622-YC2720)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2721) (CAT#: V3S-0622-YC2721)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2722) (CAT#: V3S-0622-YC2722)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2723) (CAT#: V3S-0622-YC2723)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2724) (CAT#: V3S-0622-YC2724)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2725) (CAT#: V3S-0622-YC2725)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2726) (CAT#: V3S-0622-YC2726)
Target: TNFSF13B
Host Species: Mouse
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2727) (CAT#: V3S-0622-YC2727)
Target: TNFSF13B
Host Species: Mouse
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2728) (CAT#: V3S-0622-YC2728)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2729) (CAT#: V3S-0622-YC2729)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2731) (CAT#: V3S-0622-YC2731)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2732) (CAT#: V3S-0622-YC2732)
Target: TNFSF13B
Host Species: Mouse
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2733) (CAT#: V3S-0622-YC2733)
Target: TNFSF13B
Host Species: Mouse
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2734) (CAT#: V3S-0622-YC2734)
Target: TNFSF13B
Host Species: Mouse
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2735) (CAT#: V3S-0622-YC2735)
Target: TNFSF13B
Host Species: Mouse
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2736) (CAT#: V3S-0622-YC2736)
Target: TNFSF13B
Host Species: Mouse
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2737) (CAT#: V3S-0622-YC2737)
Target: TNFSF13B
Host Species: Mouse
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2738) (CAT#: V3S-0622-YC2738)
Target: TNFSF13B
Host Species: Mouse
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2739) (CAT#: V3S-0622-YC2739)
Target: TNFSF13B
Host Species: Mouse
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2740) (CAT#: V3S-0622-YC2740)
Target: TNFSF13B
Host Species: Mouse
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2741) (CAT#: V3S-0622-YC2741)
Target: TNFSF13B
Host Species: Mouse
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2742) (CAT#: V3S-0622-YC2742)
Target: TNFSF13B
Host Species: Mouse
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2743) (CAT#: V3S-0622-YC2743)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2744) (CAT#: V3S-0622-YC2744)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2745) (CAT#: V3S-0622-YC2745)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B Neutralizing Antibody (V3S-0622-YC2746) (CAT#: V3S-0622-YC2746)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: FuncS,
Anti-TNFSF13B (aa 133-285) Neutralizing Antibody (V3S-0522-YC1986) (CAT#: V3S-0522-YC1986)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: ELISA,Neut,
Anti-TNFSF13B (aa 34-285) Neutralizing Antibody (V3S-0522-YC1987) (CAT#: V3S-0522-YC1987)
Target: TNFSF13B
Host Species: Human
Target Species: Human, Monkey,
Application: ELISA,FC,Inhib,
Rat Anti-TNFSF13B Neutralizing Antibody (V3S-0822-YC2548) (CAT#: V3S-0822-YC2548)
Target: TNFSF13B
Host Species: Rat
Target Species: Human, Mouse,
Application: Neut,FC,IHC,IHC-Fr,
Recombinant Anti-TNFSF13B (aa 134-284) Antibody (V3S-1022-YC62) (CAT#: V3S-1022-YC62)
Target: TNFSF13B
Host Species: Mouse
Target Species: Human,
Application: ELISA,
Recombinant Anti-TNFSF13B Antibody (V3S-1022-YC1375) (CAT#: V3S-1022-YC1375)
Target: TNFSF13B
Host Species: Mouse
Target Species: Human,
Application: ELISA,FC,
Recombinant Anti-TNFSF13B Antibody (V3S-1222-YC1438) (CAT#: V3S-1222-YC1438)
Target: TNFSF13B
Host Species: Human
Target Species: Human,
Application: Inhib,