| Description | This product is a human monoclonal antibody that binds human Colony Stimulating Factor-1 Receptor (CSF-1R). Antibody 1 binds to the human but not mouse CSF-IR and inhibits CSF-1 binding to human CSF-1 R. The antibody was found to internalize and induce CSF-1R degradation. It also can be used to stimulate ADCC in cell such as monocytes, macrophages and tumors. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Human |
| Epitope | Antibody 1 primarily binds to the second Ig domain of CSF-1R. |
| Affinity | 0.8 nM |
| Isotype | IgG1 |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein A affinity purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | ELISA; Block; ADCC; FuncS |
| Application Notes | The antibody is recommended for detection of CSF1R by ELISA, Block, ADCC, FuncS assays. |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | CSF1R |
| Alternative Name | FMS; CSFR; FIM2; HDLS; C-FMS; CD115; CSF-1R; BANDDOS; M-CSF-R; macrophage colony-stimulating factor 1 receptor; CD115 antigen; CSF-1 receptor; FMS proto-oncogene; McDonough feline sarcoma viral (v-fms) oncogene homolog; macrophage colony stimulating factor I receptor; proto-oncogene c-Fms |
| Gene ID | 1436 |
| UniProt | P07333 |
| Research Area | Cardiovascular; Immunology |
