Neutralizing Antibody Points

Neutralizing antibodies are a class of antibodies that neutralize the activity of pathogens. After binding to pathogens, they prevent them from further infecting host cells and block the replication and spread of pathogens. Neutralizing antibodies develop valuable roles in the immune system and protect the organism from infections. Creative Biolabs offers a comprehensive range of customization services related to neutralizing antibodies.

Neutralizing Antibody Mechanism

Neutralizing vs Non-neutralizing Antibody

There are some differences between neutralizing antibodies and other non-neutralizing antibodies such as binding antibodies, blocking antibodies, regulatory antibodies, and inhibitory antibodies in terms of the mechanisms, effects, and applications.

	Mechanisms	Effects	Applications	Evaluation Principles
Neutralizing Antibody	Neutralizing effects are achieved through direct blockade, induction of cytotoxicity, and induction of complement activation.	Direct blockade of pathogen replication and transmission delivers immediate protection and reduces disease severity.	Mainly in the prevention and treatment of viral infections, often used in vaccine development, immunotherapy, and disease diagnosis.	Measurement of the ability to neutralize pathogen-infected host cells.
Non-neutralizing Antibody	They act through other mechanisms, such as the promoting phagocytosis of pathogens and modulating the inflammatory response.	Controls pathogen infection through a variety of modes of action.	Widely used in the treatment and prevention of various diseases. For example, in the treatment of tumors and autoimmune diseases.	Usually involves the assessment of their function, efficacy, and effectiveness.

Neutralizing Antibody Evaluation

Neutralization test

Determining whether the neutralizing antibodies can prevent the pathogen from infecting and replicating in host cells by exposing the pathogen to the neutralizing antibodies.

Virus neutralization assay

Measurement of the neutralizing effect of antibodies on virus-infected host cells using living viruses or pseudoviral systems.

In vitro neutralization assay

Evaluating the ability of antibodies to neutralize pathogens by using intact antigenic epitopes or cellular models of adapted pathogens.

Mouse protection assay

Injection of neutralizing antibodies and observation of the protective effect against pathogen infection in mice.

Neutralizing Antibody Research Areas

Neutralizing Antibody Resources

Creative Biolabs also summarizes key resources such as tools and databases to broaden your view of neutralizing antibodies.

Fig. 1 Neutralizing antibody secretion and its action mechanism. (Ajmeriya, 2022)

Creative Biolabs, as a group with extensive experience in providing neutralizing antibody-related research services, is committed to accelerating clients' neutralizing antibody projects. Please contact us to learn more.

REFERENCE

Ajmeriya, S.; et al. Neutralizing antibodies and antibody-dependent enhancement in COVID-19: A perspective. J Indian Inst Sci. 2022;102(2): 671-687.

HOT TARGETS

PDCD1 HIV1 gp120 CD33 IAV HA PRNP TNF MS4A1 CD274 APP EGFR CD40 ERBB3 TFPI ERBB2 SARS-CoV S PCSK9 MET BSG HAVCR2 IL6 CD3 LAG3 ROR1 TNFRSF4 IL33 CD19 CD38 JAG1 IL17A IFNG CD47 HCV E2 Protein IL1A / IL1B HBsAg IGF1R CD4 AXL ANGPT2 IL23A NGF MUC1 TNFRSF18 TNFRSF9 MSTN IL1B HRSV F Protein KDR SORT1 C5 VEGF CXCR4 TNFRSF17 Tau TFRC CTLA4 IL13 IAV H5N1 HA TSLP MSLN SOST

For research use only, not directly for clinical use.