MS4A1 Specific Neutra™ Antibody Products
Product listMS4A1, also known as CD20, is a non-glycosylated protein of 33-37 kDa, commonly recognized as the universal B-cell marker. Expression for MS4A1 initiates in the late-stage pre-B lymphocytes and ceases in plasmablasts or plasma cells. Studies about its functionality have affirmed that MS4A1 is essential for effective B-cell BCR signal transduction. Its activation is associated with various B cell surface factors and plays a critical role in B cell activation, proliferation, and differentiation.
Its Gene ID: 931, UniProtKB ID: P11836, and OMIM ID: 112210.
Fig.1 MS4A1 and related signaling.1
MS4A1 Biology
MS4A1 serves as the universal B-cell marker, but its precise biological function is yet to be fully elucidated. Research reveals that MS4A1 interacts with multiple surface proteins, including B-cell receptors, CD53, CD81, and CD82, activating functional BCR signal pathways or other downstream signals. MS4A1 is considered one of the key signaling molecules necessary for T-dependent antigen reactions and T-independent humoral immune processes, as consistent with data obtained from MS4A1 mouse models.
MS4A1 Pathology
- MS4A1 in Cancer
In malignant B-cell tumors, MS4A1 exhibits variations in expression levels according to different tumor types. MS4A1 is considered as a potential therapeutic target for intervention in malignant B-cell tumors. Targeted antibody drugs have indeed been developed that demonstrate efficacy in B-cell leukemia and lymphomas, effectively enhancing overall survival rates and progression-free survival rates.
Fig.2 Therapeutic effects of MS4A1.2
- MS4A1 in Multiple Sclerosis (MS)
With the advancing research into the pathology and immunology principles of MS, its molecular background is gradually shifting from T-cell mediated to B-cell mediated. Therefore, anti-MS4A1 antibody intervention is believed to be a prospective strategy for extended targeted intervention in MS.
Fig.3 Therapeutic effects of MS4A1 in MS.2
Creative Biolabs offers a wide range of MS4A1-related products alongside one-stop comprehensive antibody services, aiding in exploring the boundless potential of MS4A1. Please feel free to explore the full potential of our neutralizing antibody platform and recombinant antibody platform.
REFERENCES
- Pavlasova, Mraz, et al. "The regulation and function of CD20: an "enigma" of B-cell biology and targeted therapy." Haematologica 105.6 (2020): 1494-1506.
- Chmielewska, Szyndler, et al. " Targeting CD20 in multiple sclerosis — review of current treatment strategies." Polish Journal of Neurology and Neurosurgery 57.3 (2023): 235-242.
