SARS-CoV-2 S protein

Product list

The devastation caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made clear the importance of pandemic preparedness. To address future zoonotic outbreaks due to related viruses in the sarbecovirus subgenus, we identified a human monoclonal antibody, 10-40, that neutralized or bound all sarbecoviruses tested in vitro and protected against SARS-CoV-2 and SARS-CoV in vivo. Comparative studies with other receptor-binding domain (RBD)-directed antibodies showed 10-40 to have the greatest breadth against sarbecoviruses, suggesting that 10-40 is a promising agent for pandemic preparedness. Moreover, structural analyses on 10-40 and similar antibodies not only defined an epitope cluster in the inner face of the RBD that is well-conserved among sarbecoviruses, but also uncovered a distinct antibody class with a common CDRH3 motif. Our analyses also suggested that elicitation of this class of antibodies may not be overly difficult, an observation that bodes well for the development of a pan-sarbecovirus vaccine.

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Anti-SARS-CoV-2 S protein Neutralizing Antibody (V3S-0623-XY41) (CAT#: V3S-0623-XY41)

Target: SARS-CoV-2

Host Species: Human

Target Species: SARS-CoV-2,

Application: ELISA, Neut,

Anti-SARS-CoV-2 S protein (SD1) Neutralizing Antibody (V3S-0623-XY48) (CAT#: V3S-0623-XY48)

Target: SARS-CoV-2

Host Species: Human

Target Species: SARS-CoV-2,

Application: ELISA, Neut,

Anti-SARS-CoV-2 S protein (N-terminus) Neutralizing Antibody (V3S-0623-XY77) (CAT#: V3S-0623-XY77)

Target: SARS-CoV-2

Host Species: Human

Target Species: SARS-CoV-2,

Application: ELISA, Neut,

Anti-SARS-CoV-2 S protein Neutralizing Antibody (V3S-0623-XY84) (CAT#: V3S-0623-XY84)

Target: SARS-CoV-2

Host Species: Human

Target Species: Omicron BA.2 and BA.4/5,

Application: ELISA, Neut,

Anti-SARS-CoV-2 S protein (NTD) Neutralizing Antibody (V3S-0623-XY95) (CAT#: V3S-0623-XY95)

Target: SARS-CoV-2

Host Species: Human

Target Species: SARS-CoV-2,

Application: ELISA, Neut,

Anti-SARS-CoV-2 S protein Neutralizing Antibody (V3S-0623-XY103) (CAT#: V3S-0623-XY103)

Target: SARS-CoV-2

Host Species: Human

Target Species: Omicron BA.2 and BA.4/5,

Application: ELISA, Neut,

Anti-SARS-CoV-2 S protein Neutralizing Antibody (V3S-0623-XY104) (CAT#: V3S-0623-XY104)

Target: SARS-CoV-2

Host Species: Human

Target Species: SARS-CoV-2,

Application: ELISA, Neut,

Anti-SARS-CoV-2 S protein (SD1) Neutralizing Antibody (V3S-0623-XY108) (CAT#: V3S-0623-XY108)

Target: SARS-CoV-2

Host Species: Human

Target Species: SARS-CoV-2,

Application: ELISA, Neut,

Anti-SARS-CoV-2 S protein (NTD) Neutralizing Antibody (V3S-0623-XY111) (CAT#: V3S-0623-XY111)

Target: SARS-CoV-2

Host Species: Human

Target Species: SARS-CoV-2,

Application: ELISA, Neut,

Anti-SARS-CoV-2 S protein (NTD) Neutralizing Antibody (V3S-0623-XY121) (CAT#: V3S-0623-XY121)

Target: SARS-CoV-2

Host Species: Human

Target Species: SARS-CoV-2,

Application: ELISA, Neut,

Recombinant Anti-SARS-CoV-2 S protein (NTD) Antibody (V3S-0623-XY135) (CAT#: V3S-0623-XY135)

Target: SARS-CoV-2

Host Species: Human

Target Species: SARS-CoV-2,

Application: ELISA,

SARS-CoV-2 S protein Specific Neutra™ Antibody (V3S-0723-WK35), Human IgG (CAT#: V3S-0723-WK35)

Target: SARS-CoV-2 S protein

Host Species: Human

Target Species: SARS-CoV-2,

Application: ELISA,SPR,

SARS-CoV-2 S (aa 750-1000) Specific Recomb™ Antibody (V3S-1123-CJ20), Chicken IgY (CAT#: V3S-1123-CJ20)

Target: SARS-CoV-2 S protein

Host Species: Chicken

Target Species: SARS-CoV-2,

Application: ELISA,ICC,WB,

For research use only, not directly for clinical use.

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