| Description | The antibody is a chimeric monoclonal antibody that binds to structurally-related stimulants (i.e. (+)-methamphetamine (METH), (+)-amphetamine and (+)-MDMA), neurotransmitters (i.e.(+) - Dopamine, (-) - Norepinephrine, (-)-Epinephrine, Serotonin, γ-aminobutyric acid and L-Glutamate), selected medications ((+) - Pseudoephedrine, (+)-Norpseudoephedrine, (-)-Phenylephrine, (±)-Ephedrine, 2-Phenylethylamine and Tyramine), and other drugs of abuse ((-)-MDMA, (+)-MDA, Cocaine, Morphine and PCP). The mAb was designed to maintain the variable framework regions of the heavy and light chains of the mouse antibody including all three CDRs of both the heavy and the light chains. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Non-species dependence |
| Immunogen | METH-like hapten (S)-(+)-3-(9-carboxynonyloxy)methamphetamine was covalently bound to bovine serum albumin (BSA) |
| Isotype | IgG |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein A affinity purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | ELISA; FuncS |
| Application Notes | The antibody is recommended for detection of (+) MDMA by ELISA, FuncS assays. |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | (+) MDMA |
| Alternative Name | (+) Methamphetamine; Methamphetamine; dextromethamphetamine |
| Research Area | Neuroscience |
