ABA Specific Neutra™ Antibody Products

Struggling with challenges in plant stress physiology studies or metabolic disorder therapeutic development? Creative Biolabs' ABA-specific Neutra™ antibodies leverage advanced hybridoma screening and epitope-specific engineering to deliver high-affinity, validated tools for precise ABA neutralization, accelerating drug discovery and agricultural innovation.

Introduction to ABA

Abscisic acid (ABA) is a critical phytohormone regulating plant responses to environmental stressors such as drought, salinity, and pathogen attack. Beyond its canonical role in plants, ABA also functions as an endogenous signaling molecule in mammals, modulating glucose homeostasis, inflammatory responses, and cardiovascular functions. Its dual significance in plant biology and human pathophysiology positions ABA as a pivotal target for therapeutic and agricultural research.

• Basic Information

ABA, a sesquiterpenoid compound (C₁₅H₂₀O₄), is synthesized in plant chloroplasts and plastids under stress conditions. In mammals, ABA is endogenously produced in pancreatic β-cells, granulocytes, and vascular tissues. It binds to LANCL2 and PYR/PYL/RCAR receptors in mammals, activating downstream pathways influencing insulin release and immune modulation.

Fig.1 ABA biosynthesis pathway.^1,3

• Structural Insights

The ABA molecule comprises a cyclohexene ring with a side chain containing a carboxylic acid group and a hydroxylated methyl branch. Structural analogs with modified side chains exhibit varied receptor-binding affinities, highlighting the importance of stereospecificity for functional studies. Antibodies targeting the C-1' hydroxyl or C-4' ketone groups enable selective recognition of bioactive ABA isoforms.

• Relevant Signaling Pathways

In plants, ABA triggers stomatal closure via SnRK2 kinase activation and ROS signaling. In mammals, ABA stimulates insulin secretion through cyclic AMP-PKA pathways and modulates macrophage polarization via PPARγ. Its cross-kingdom signaling complexity necessitates tools capable of dissecting context-specific interactions.

Fig.2 Role of ABA in plant development and stress response.^2,3

• Associated Pathologies

Dysregulated ABA signaling is implicated in metabolic syndrome, type 2 diabetes, and hypertension. Elevated ABA levels correlate with β-cell dysfunction and impaired glucose tolerance. Conversely, ABA deficiency in crops exacerbates yield loss under abiotic stress, underscoring its translational relevance.

Applications of Anti-ABA Neutralizing Antibodies

• Therapeutic Development for Metabolic Disorders

Anti-ABA antibodies reduce hyperglycemia in diabetic models by blocking ABA-LANCL2 interactions, restoring insulin sensitivity. Clinical trials explore their potential for adjunct therapy in metabolic syndrome.

• Plant Stress Tolerance Engineering

Antibody-mediated ABA depletion in crops under controlled hydroponic systems identifies genes critical for drought resistance, expediting the development of stress-resilient cultivars.

• Diagnostic Assay Development

- Portable ABA Detection Kits: Field-deployable lateral flow assays integrating our antibodies enable real-time monitoring of crop stress levels, informing irrigation strategies.

- Precision Agriculture: UAV-mounted sensors coupled with ABA immunoassays optimize water-use efficiency in large-scale farming.

• Immune Modulation Studies

Anti-ABA antibodies inhibit pro-inflammatory cytokine secretion (e.g., TNF-α, IL-6) in macrophages, offering a novel approach to mitigate chronic inflammation in obesity-linked disorders.

• Target Validation in Drug Discovery

High-throughput screening platforms using fluorescence-polarized ABA-antibody complexes identify small-molecule inhibitors of ABA biosynthesis, accelerating lead compound development.

Our Anti-ABA Antibody Products

Creative Biolabs offers anti-ABA neutralizing antibodies that represent the gold standard for stress biology and metabolic research, combining epitope precision, species cross-reactivity, and assay-ready formulations. With batch-to-batch consistency certified, our products empower researchers to decode ABA's multifaceted roles and translate findings into therapeutic or agricultural breakthroughs.

The anti-ABA neutralizing antibodies are rigorously validated for specificity against bioactive ABA isoforms, with no cross-reactivity to structurally related phytohormones (e.g., JA, SA). Engineered for high neutralizing capacity (IC₅₀ <1 nM), these antibodies enable:

- Quantification of ABA in plant/plasma samples via competitive ELISA (detection limit: 0.2 pg/mL).

- In vivo neutralization of ABA in murine models to study glucose metabolism.

- Immunoprecipitation of ABA-receptor complexes for structural studies.

Key validations include mass spectrometry-confirmed epitope mapping and performance benchmarking across 15+ plant and mammalian species. Contact our scientific team today to customize antibody panels for your specific model systems.

REFERENCES

1. Ali, Shahid, et al. "Implications of abscisic acid in the drought stress tolerance of plants." Agronomy 10.9 (2020): 1323. https://doi.org/10.3390/agronomy10091323
2. Felemban, Abrar, et al. "Apocarotenoids involved in plant development and stress response." Frontiers in plant science 10 (2019): 1168. https://doi.org/10.3389/fpls.2019.01168
3. Distributed under Open Access license CC BY 4.0, without modification.