Relying on a robust technological platform and innovative technologies, Creative Biolabs now possesses the capability to deliver high-throughput neutralizing antibody detection services that are efficient and precise for our esteemed clientele worldwide.
Creative Biolabs has established comprehensive standardized testing procedures for enzyme-linked immunosorbent micro-neutralization assays or pseudovirus assays as excellent alternatives to traditional plaque reduction neutralization tests with high-throughput biological functional assessment reports for any target antibody with enhanced efficiency.
Furthermore, our cutting-edge microfluidic research platform is empowered to swiftly identify and analyze single-virus droplets and their antibody recognition epitopes with exceptional efficiency. Combined with next-generation sequencing technologies, we can rapidly and efficiently identify, sort, and analyze virus particles displaying neutralizing epitopes.
Fig.1 High-throughput neutralizing antibody assay. 1
Our optimized research workflows and advanced technological platforms endow us with unparalleled competitiveness. By choosing Creative Biolabs, you are embracing:
Title: Development and evaluation of a novel high-throughput image-based fluorescent neutralization test for detection of Zika virus infection
The research aims to develop a high-throughput screening and detection template for yellow fever virus-neutralizing antibodies based on enzyme-linked immunosorbent assays.
The study utilizes micro-neutralization assays and employs colorimetric assays to determine the inhibitory effect of neutralizing antibodies on virus growth. Neutralization activity and antibody-dependent enhancement (ADE) activity are measured as indicators of neutralizing potency, and are compared with the endpoint titers of traditional plaque reduction neutralization tests.
The results of the neutralization tests indicate a strong correlation between the micro-neutralization test results and the endpoint titers of plaque reduction neutralization tests. The new micro-neutralization assay can combine accurate assessment of virus neutralization activity with the reliability and practicality of ELISA technology. This technology can be used for high-throughput detection of virus antibody neutralization activity, contributing to various epidemiological investigations and potential vaccine efficacy assessments.
Fig.3 Fluorescent neutralization assay.2
Experience the difference with Creative Biolabs as we invite you to connect with us and unlock the potential of our cutting-edge neutralizing antibody assay services. Reach out to us now and let us partner with you in advancing scientific discovery and innovation.