Vasohibin is a polypeptide of the present invention have found, Vasohibin 1 and Vasohibin 2 belongs as homolog body. These Vasohibin tumor cells and stromal cells, by stimulation of angiogenic factors secreted from such as macrophages (VEGF, FGF-2, etc.) are expressed in vascular endothelial cells, autocrine manner acts on the endothelial cells themselves Te, have been known to have action to inhibit angiogenesis.