| Description | This antibody was generated by immunizing with the ADCYAP1R1 (also known as PAC1) extracellular domain protein. The antibody binds to human and cynomolgus PAC1 and also for functional antagonist activity in an assay detecting their ability to block generation of cAMP by activation of PAC1 with either PACAP. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Human |
| Epitope | The epitope is located in the extracellular domain. |
| Affinity | KD = 0.024 nM |
| Isotype | IgG2 kappa |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein A affinity purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | Block; FuncS |
| Application Notes | The antibody is recommended for detection of ADCYAP1R1 by Block, FuncS assays. |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | ADCYAP1R1 |
| Alternative Name | PAC1; PAC1R; PACAPR; PACAPRI; pituitary adenylate cyclase-activating polypeptide type I receptor; PACAP receptor 1; PACAP type I receptor; PACAP-R1; adenylate cyclase; activating polypeptide 1 (pituitary) receptor type I; pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop; pituitary adenylate cyclase-activating; polypeptide type 1 receptor |
| Gene ID | 117 |
| UniProt | P41586 |
| Research Area | Neuroscience; Signal Pathway |
