This antibody was generated by immunizing with the ADCYAP1R1 (also known as PAC1) extracellular domain protein. The antibody binds to human and cynomolgus PAC1 and also for functional antagonist activity in an assay detecting their ability to block generation of cAMP by activation of PAC1 with either PACAP.
The epitope is located in the extracellular domain.
KD = 0.024 nM
HEK293F or CHO
>95%, determined by SDS-PAGE and SEC-HPLC
Protein A affinity purified
0.2 μM filtered
PBS, pH 7.4
Store at 4°C within a week. For longer storage, aliquot and store at -20°C.
The antibody is recommended for detection of ADCYAP1R1 by Block, FuncS assays.