| Description | 21D9 is a human antibody that is known for its ability to bind Anthrax PA toxin. Specifically, 21D9 targets a distal linear epitope within the PA47 polypeptide, effectively impeding PA oligomer formation by potentially concealing assembly interfaces. Notably, the IC₅₀ value for 21D9 is measured at 0.21 nM. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Bacillus anthracis |
| Immunogen | Fully human monoclonal antibody or fragment thereof that recognizes at least a portion of an anthrax exotoxin. |
| Epitope | Carboxyl domain PA47 |
| Affinity | KD = 82.1 pM |
| Isotype | Human IgG |
| Expression Species | HEK293F or CHO Cell line |
| Conjugation | Unconjugated, also available for Biotin, HRP, FITC and PE-labeled form. |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg, determined by LAL method |
| Purification | Purified with Protein A or G affinity chromatography |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics. |
| Application | ELISA |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | Anthrax toxin PA |
| Alternative Name | Anthrax Protective Antigen (PA) Toxin; Anthrax toxin PA |
| Research Area | Infectious Disease |
| Related Disease | Infectious Diseases |
