CMV gB (aa 68-81) Specific Neutra™ Antibody (V3S-0923-XY2), Human IgG (CAT#: V3S-0923-XY2)

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Description This product TRL345-I8 is a human neutralizing antibody binding CMV gB (Cytomegalovirus glycoprotein B), which is required for viral entry into host cells. It targets antigenic domain 2 site 1 (AD-2S1) of gB and has high binding affinity. TRL345-I8 shows highly potent and broad neutralization ability against CMV.
Clonality Monoclonal
Host Species Human
Target Species Cytomegalovirus (CMV)
Epitope It targets antigenic domain 2 site 1 (AD-2S1), which is a linear epitope at the N-terminus of gB (amino acids 68-81).
Neutralization Mechanism Stabilize the gB AD-2S1 peptide in this conformation
Affinity 4.8 ng/mL
Isotype Human IgG


Expression Species HEK293F or CHO cell line
Conjugation Unconjugated
Purity >95%
Endotoxin <1 EU/mg
Form Liquid
Purification Protein A purified
Sterility 0.2 μM filtered
Formulation PBS, pH 7.4
Preservation No preservatives
Stabilizer No stabilizers
Storage Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics.


Application ELISA; SPR; Neut
Application Notes ELISA: mAb was plated in a 12-point 3-fold serial dilution at a starting concentration of 1 μg/mL.
Surface plasmon resonance (SPR): Monoclonal antibody (10 μg/mL) was non-covalently captured on the surface of a Series S Sensor Chip Protein A by injection for 60 s at a flow rate of 5 μL/min.
Neutralization assay (Neut): mAb was coincubated at a starting concentration of 50 μg/mL (50 μg/mL to 22.9 ng/mL). Virus and antibody mixtures were added to cells and allowed to incubate for 16 to 24 h at 37°C.


ELISA Enzyme-Linked Immunosorbent Assay Protocol
WB Western Blot Protocol
FC Flow Cytometry Protocol


Target CMV gB
Alternative Name Cytomegalovirus glycoprotein B
Research Area Infectious Disease
Related Disease Permanent hearing loss; Cognitive impairment; Retinitis; Cerebral palsy
For research use only, not directly for clinical use.
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