| Description | This recombinant human antibody has been designed to specifically target human CXCR4. With a notable affinity of 0.68 nM for human CXCR4, this antibody demonstrates the capability to impede the binding of human CXCR4 to SDF-1. Furthermore, its efficacy extends to inhibiting tumorigenesis activity, thereby playing a crucial role in impeding tumor growth. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Human |
| Affinity | KD = 0.68 nM |
| Isotype | Human IgG |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein A affinity purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | Inhib |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | CXCR4 |
| Alternative Name | C-X-C Motif Chemokine Receptor 4; Leukocyte-Derived Seven Transmembrane Domain Receptor; Lipopolysaccharide-Associated Protein 3; Stromal Cell-Derived Factor 1 Receptor; Chemokine (C-X-C Motif) Receptor 4; LPS-Associated Protein 3; SDF-1 Receptor; CD184 Antigen; Fusin; LAP-3; LESTR; NPYRL; FB22; HM89; LCR1; Seven-Transmembrane-Segment Receptor, Spleen; Chemokine (C-X-C Motif), Receptor 4 (Fusin) |
| Gene ID | 7852 |
| UniProt | P61073 |
| Related pathway | Class A/1 (Rhodopsin-like receptors) and HIV Life Cycle |
| Research Area | Signal Pathway |
| Related Disease | Whim Syndrome 1 and Macroglobulinemia |
