| Description | mAb 092096 is a neutralizing antibody against Plasmodium vivax Duffy binding protein (DBP) region II (DBP-II). mAb 092096 targets the receptor-binding residues and dimer interface of DBP. mAb 092096 demonstrated clear competition with high-blocking activity polysera. mAb 092096 can neutralize invasion of reticulocytes by multiple P. vivax isolates from distinct geographical locations. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Plasmodium vivax |
| Epitope | A discontinuous conformational epitope comprising residues of Y219, E249, L270-K289 and Q356-W375. |
| Neutralization Mechanism | Preventing DBP-II binding to the N-terminus of DARC. |
| IC50 | 1.63 ± 1.07 nM |
| Affinity | KD = 7.63 ± 0.29 nM |
| Isotype | Human IgG1 |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein A purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | ELISA; Neut; BLI |
| Application Notes | ELISA: 250 ng/mL |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | DBP |
| Alternative Name | Duffy binding protein; Duffy binding surface protein region II; Duffy binding surface protein; DBP-II; region II; Duffy Binding Like (DBL) domain |
| Research Area | Cell Biology |
