| Description | This is a mouse monoclonal antibody that specifically targets the human DLL4 protein. Its binding affinity is directed towards a specific region encompassing the MNNL domain. The antibody was developed using the soluble human Dll4-His protein (amino acids 1-524) as the immunogen. Notably, it demonstrates effective neutralization of the Dll4-Notch1 interaction. |
| Clonality | Monoclonal |
| Host Species | Mouse |
| Target Species | Human |
| Immunogen | The soluble human D114-His protein (AA 1-524). |
| Epitope | Binds to a region that includes the MNNL domain. |
| Isotype | Mouse IgG, lambda |
| Expression Species | HEK293F or CHO Cell line |
| Conjugation | Unconjugated, also available for Biotin, HRP, FITC and PE-labeled form. |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg, determined by LAL method |
| Purification | Purified with Protein A or G affinity chromatography |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within one or two weeks. Store at -20°C for long term. Avoid repeated freeze/thaw cycles. Refer to the COA file for specifics. |
| Application | ELISA; Neut |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | DLL4 |
| Alternative Name | Delta Like Canonical Notch Ligand 4; Drosophila Delta Homolog 4; Delta4; Delta-Like 4 Homolog (Drosophila); Delta-Like 4 (Drosophila); Delta-Like 4 Homolog; Delta-Like 4 Protein; Delta-Like Protein 4 |
| Gene ID | 54567 |
| UniProt | Q9NR61 |
| Related pathway | NOTCH2 Activation and Transmission of Signal to the Nucleus and Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| Research Area | Signal Pathway |
| Related Disease | Adams-Oliver Syndrome 6 and Adams-Oliver Syndrome |
