| Description |
This product is a human monoclonal antibody that reacts with seven human ELR+ CXC chemokines. The antibody binds to a conformational epitope and does not work in western blot under reducing conditions. The epitope mapping analysis for Antibody 1 demonstrated that the binding interface of the antigen includes the N-terminus of the ELR+ CXC chemokines (amino acids 5-13), the β1-β2 loop (amino acids 33-36), and the β2 and β3 strands (amino acids 40, 48-50). Key contacts that are important for antibody binding include the amino acids R6, I10, A35, I40, and L49 in CXCL8. |
| Clonality |
Monoclonal |
| Host Species |
Human |
| Target Species |
Human |
| Epitope |
Key contacts that are important for antibody binding include the amino acids R6, I10, A35, I40, and L49 in CXCL8. |
| Affinity |
0.12 nM for CXCL1, 0.18 nM for CXCL2, 0.18 nM for CXCL3, 0.25 nM for CXCL5, 0.85 nM for CXCL6, 0.22 nM for CXCL7, 0.39 nM for CXCL8 |
| Isotype |
IgG4 |
