| Description | This chimeric 4D5 antibody binds to HER2/neu, which has reduced glycosylation compared to known 4D5 antibodies. The antibody can function in ADCC, block, and flow cytometer assays. |
| Clonality | Monoclonal |
| Host Species | Human |
| Target Species | Human |
| Epitope | Amino acids 529-627 |
| Isotype | Human IgG |
| Expression Species | HEK293F or CHO |
| Conjugation | None |
| Purity | >95%, determined by SDS-PAGE and SEC-HPLC |
| Endotoxin | <1 EU/mg |
| Purification | Protein A affinity purified |
| Sterility | 0.2 μM filtered |
| Formulation | PBS, pH 7.4 |
| Preservation | No preservatives |
| Stabilizer | No stabilizers |
| Storage | Store at 4°C within a week. For longer storage, aliquot and store at -20°C. |
| Application | Block; ADCC; FC |
| ELISA | Enzyme-Linked Immunosorbent Assay Protocol |
| WB | Western Blot Protocol |
| FC | Flow Cytometry Protocol |
| Target | ERBB2 |
| Alternative Name | Erb-B2 Receptor Tyrosine Kinase 2; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2; Tyrosine Kinase-Type Cell Surface Receptor HER2; Neuro/Glioblastoma Derived Oncogene Homolog; Human Epidermal Growth Factor Receptor 2; Metastatic Lymph Node Gene 19 Protein; Proto-Oncogene C-ErbB-2; Proto-Oncogene Neu; EC 2.7.10.1; P185erbB2; MLN 19; HER2; NGL; NEU; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2 (Neuro/Glioblastoma Derived Oncogene Homolog) |
| Gene ID | 2064 |
| UniProt | P04626 |
| Related pathway | Signal Pathway, Cancer Research, Autophagy |
| Research Area | Signal Pathway |
| Related Disease | Cancer, autoimmune diseases, inflammatory disorders, and infectious disease |
